{"hq_id":"hq-c-org-000137","name":"Bromacil","context":"human_adult","timestamp":"2026-10-27T18:50:31.679Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000137","sha256":"5282e6433053e6bf021c2e8e08bd16c47643476e8635a632d96f830e85eeb986"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.392599,"weightedMean":0.392599,"std_dev":0.099726,"confidence_interval_95":[0.3,0.5],"source_positions":[{"source":"EPA CTX / EPA OPP","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.33516,"disagreement_magnitude":0.363517,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / EPA OPP classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"epa_bromacil_registration","type":"regulatory","title":"US EPA: Bromacil Registration Eligibility Decision — Group C Carcinogen (Testicular Tumors), Groundwater Contamination, MCL, and Dietary Risk Assessment (2004)","year":2004},{"id":"r60-2026-09-26-d867-cc2-ecfr-40cfr141.61","type":"regulatory","title":"§ 141.61 Maximum contaminant levels for organic contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-40.xml?part=141&section=141.61"},{"id":"r60-2026-09-28-d899-s2-b02-epa-npdwr-table","type":"regulatory","title":"National Primary Drinking Water Regulations | US EPA","url":"https://www.epa.gov/ground-water-and-drinking-water/national-primary-drinking-water-regulations"},{"id":"r60-2026-09-28-d449-nepis-20000KA7-pdftotext","type":"regulatory","title":"Reregistration Eligibility Decision (RED) Bromacil","url":"https://nepis.epa.gov/Exe/ZyPDF.cgi/20000KA7.PDF?Dockey=20000KA7.PDF"},{"id":"r60-2026-09-26-d867-cc4-epa-dwsha-tables-2018","type":"regulatory","title":"2018 Edition of the Drinking Water Standards and Health Advisories Tables (EPA 822-F-18-001)","url":"https://www.epa.gov/system/files/documents/2022-01/dwtable2018.pdf"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_9411","type":"pubchem","title":"PubChem: Toxicity section (CID 9411)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/9411/JSON?heading=Toxicity"},{"id":"r60-2026-10-03-d923-niosh-npgd0063","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Bromacil","url":"https://www.cdc.gov/niosh/npg/npgd0063.html"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-9411","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 9411; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/9411/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid4022020","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID4022020 (Bromacil)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID4022020"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 3 (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":53,"warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 3 (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","human_child","exposure_inhalation","exposure_dermal","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}