{"hq_id":"hq-c-org-000132","name":"Pendimethalin","context":"human_adult","timestamp":"2026-10-27T17:56:09.772Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000132","sha256":"5878eef052df57e4ee56a831671ef2de74b782efcbac15b16be41af913493d9f"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.300467,"weightedMean":0.300467,"std_dev":0.009658,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"EPA CTX / EPA OPP","year":1992,"value":0.5,"weight":0.00082},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.500748,"weightedMean":0.500748,"std_dev":0.015453,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":1992,"value":0.82,"weight":0.00082}]},"recency":{"mean":0.997665,"weightedMean":0.997665,"std_dev":0.048242,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":1992,"value":0.001,"weight":0.00082}]},"methodology":{"mean":0.700701,"weightedMean":0.700701,"std_dev":0.014487,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":1992,"value":1,"weight":0.00082}]},"specificity":{"mean":0.919603,"weightedMean":0.919603,"std_dev":0.008209,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":1992,"value":0.75,"weight":0.00082}]},"consensus":{"exists":false,"strength":0.935613,"disagreement_magnitude":0.501857,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / EPA OPP classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"epa_pendimethalin_registration","type":"regulatory","title":"US EPA: Pendimethalin Registration Review — Group C (Possible Human Carcinogen), Dietary and Occupational Risk Assessment, and Ecological Risk (2014–2019)","year":2019,"url":"https://downloads.regulations.gov/EPA-HQ-OPP-2018-0619-0008/content.pdf"},{"id":"r60-2026-09-29-d899-s4-b05-iris-landing-292-pendimethalin","type":"regulatory","title":"Pendimethalin | CASRN 40487-42-1 | DTXSID7024245 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=292"},{"id":"r60-2026-09-28-d899-s4-b04-epa-hhbp-2021","type":"regulatory","title":"2021 Human Health Benchmarks for Pesticides | US EPA","url":"https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides"},{"id":"r60-2026-09-27-d876-fr-2018-03277-83FR6975-raw","type":"regulatory","title":"Pendimethalin; Pesticide Tolerances","url":"https://www.federalregister.gov/documents/full_text/text/2018/02/16/2018-03277.txt"},{"id":"r60-2026-09-27-d876-fr-2019-23382-84FR57336-raw","type":"regulatory","title":"Pendimethalin; Pesticide Tolerances","url":"https://www.federalregister.gov/documents/full_text/text/2019/10/25/2019-23382.txt"},{"id":"r60-2026-09-27-d876-fr-2024-16544-89FR61351-raw","type":"regulatory","title":"Pendimethalin; Pesticide Tolerance","url":"https://www.federalregister.gov/documents/full_text/text/2024/07/31/2024-16544.txt"},{"id":"r60-2026-09-30-d907-c7ef6016b6","type":"regulatory","title":"EPA CTX","url":"https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/red_PC-108501_1-Apr-97.pdf"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"src_pubchem_tox_38479","type":"pubchem","title":"PubChem: Toxicity section (CID 38479)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/38479/JSON?heading=Toxicity"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-38479","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 38479; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/38479/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid7024245","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID7024245 (Pendimethalin)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID7024245"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":49,"warnings":["unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","exposure_ingestion","human_teen","human_elderly","human_pregnant","agricultural_worker","aquatic_life"]}