{"hq_id":"hq-c-org-000129","name":"Perfluorooctane sulfonamide (PFOSA)","context":"human_adult","timestamp":"2026-10-27T17:56:45.657Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000129","sha256":"a4c5fa630efd96dd28eb856d0ddf5040a6e80f2323d4164ff14d30552c8b538e"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_pfos_pfosa_assessment","type":"regulatory","title":"US EPA: Perfluorooctane Sulfonate (PFOS) and Perfluorooctane Sulfonamide (PFOSA) — Risk Assessment, Phase-Out, Scotchgard Legacy, and PFOSA-to-PFOS Metabolic Conversion","year":2016},{"id":"atsdr_pfas_clinical_guidance","type":"regulatory","title":"ATSDR: Clinical Guidance for Perfluoroalkyl and Polyfluoroalkyl Substances — PFOSA Precursor Status, PFOS Conversion, Neurotoxicity Profile, and Minimum Risk Levels","year":2021},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"r60-2026-10-01-dd54-pops-new-pops","type":"regulatory","title":"Stockholm Convention: The New POPs (the Convention's own index of listed chemicals)","url":"https://www.pops.int/TheConvention/ThePOPs/TheNewPOPs/tabid/2511/Default.aspx"},{"id":"r60-2026-10-02-d983-stockholm-convention-text-2025","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants: text with Annexes (2025 English)","url":"https://www.pops.int/Portals/0/download.aspx?e=UNEP-POPS-COP-CONVTEXT-2025.English.pdf"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-10-08-d972-oehha-pfos-listing-notice-2021","type":"regulatory","title":"OEHHA notice to interested parties December 24, 2021: PFOS and its salts and transformation and degradation precursors listed (operator save)","url":"https://oehha.ca.gov/sites/default/files/media/downloads/crnr/noticepfossandsaltstransdegradprecursor122421.pdf"},{"id":"r60-2026-10-08-d972-oehha-pfos-hazard-id-2021","type":"regulatory","title":"OEHHA hazard identification: Evidence on the Carcinogenicity of PFOS and its salts and transformation and degradation precursors, September 2021 (operator save)","url":"https://oehha.ca.gov/sites/default/files/media/downloads/crnr/pfoshid092421.pdf"},{"id":"ctx_pred_dtxsid3038939","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3038939 (Perfluorooctane sulfonamide (PFOSA))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3038939"}],"sources_scope":"context","derived_markers":[],"warnings":["single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":41},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","exposure_dermal","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life"]}