{"hq_id":"hq-c-org-000124","name":"PFBS (Perfluorobutane sulfonate)","context":"human_adult","timestamp":"2026-10-27T18:51:23.182Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000124","sha256":"110027e269a6d14e0af95486b0b70c98918db76584d5475d7b69f9932f485f78"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_pfbs_tox_review","type":"regulatory","title":"US EPA: Toxicological Review of Perfluorobutane Sulfonate (PFBS) — Thyroid Effects, Reference Dose (0.0003 mg/kg/day), and Hazard Index Grouping with Other Short-Chain PFAS","year":2021},{"id":"epa_pfas_mcl_2024","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulations for PFAS (April 2024 Final Rule) — PFBS in Hazard Index (HI) Mixture Approach; Cumulative Thyroid/Developmental Hazard Assessment","year":2024},{"id":"r60-2026-09-28-d899-s2-b03-epa-ha-genx-chemicals-and-pfbs","type":"regulatory","title":"Drinking Water Health Advisories for GenX Chemicals and PFBS | US EPA","url":"https://www.epa.gov/sdwa/drinking-water-health-advisories-genx-chemicals-and-pfbs"},{"id":"r60-2026-09-28-d899-s2-b03-epa-ha-pfbs-2022","type":"regulatory","title":"Drinking Water Health Advisory: Perfluorobutane Sulfonic Acid (CASRN 375-73-5) and Related Compound Potassium Perfluorobutane Sulfonate (CASRN 29420-49-3)","url":"https://www.epa.gov/system/files/documents/2022-06/drinking-water-pfbs-2022.pdf"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_67815","type":"pubchem","title":"PubChem: Toxicity section (CID 67815)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/67815/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-27-d901-partA-comptox-DTXSID5030030","type":"database","title":"D-901 AC1 part A capture: 2026-09-27-d901-partA-comptox-DTXSID5030030","url":"https://comptox.epa.gov/dashboard-api/ccdapp1/search/chemical/equal-with-detail/DTXSID5030030"},{"id":"ctx_pred_dtxsid5030030","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID5030030 (PFBS (Perfluorobutane sulfonate))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID5030030"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":47,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}