{"hq_id":"hq-c-org-000122","name":"PFHxS (Perfluorohexane sulfonic acid)","context":"human_adult","timestamp":"2026-10-27T17:56:45.264Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000122","sha256":"678b7d1fcda25d8afdfb24b72137dce79d18abcf73414318e726c0809499047c"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"iarc_135_pfas","type":"regulatory","title":"IARC Monographs Volume 135 (2023): Perfluorooctanoic Acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) — PFOA classified Group 1 (carcinogenic to humans); PFOS Group 2B. NOTE: this PFAS was NOT among the agents individually evaluated in Volume 135.","year":2023,"url":"https://www.ncbi.nlm.nih.gov/books/NBK614282/"},{"id":"epa_pfas_mcl_2024","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulations for PFAS (April 2024 Final Rule) — PFHxS Individual MCL 10 ppt; Hazard Index Mixture Grouping","year":2024,"url":"https://www.federalregister.gov/documents/2024/04/26/2024-07773/pfas-national-primary-drinking-water-regulation"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"doc-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"ctx_pred_dtxsid7040150","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID7040150 (PFHxS (Perfluorohexane sulfonic acid))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID7040150"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":46,"warnings":["unmapped_classification:IARC:not evaluated by iarc"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}