{"hq_id":"hq-c-org-000121","name":"PFNA (Perfluorononanoic acid)","context":"human_adult","timestamp":"2026-10-27T18:59:21.429Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000121","sha256":"021e3d3de2facaf4372b4329bcf7c087912cf3870a84b2a8d81f1a3b8ebc5136"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"iarc_135_pfas","type":"regulatory","title":"IARC Monographs Volume 135 (2023): Perfluorooctanoic Acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) — PFOA classified Group 1 (carcinogenic to humans); PFOS Group 2B. NOTE: this PFAS was NOT among the agents individually evaluated in Volume 135.","year":2023,"url":"https://www.ncbi.nlm.nih.gov/books/NBK614282/"},{"id":"epa_pfas_mcl_2024","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulations for PFAS (April 2024 Final Rule) — Individual MCLs for PFOA (4 ppt), PFOS (4 ppt), PFNA (10 ppt), PFHxS (10 ppt), HFPO-DA (10 ppt); Hazard Index for Mixtures","year":2024,"url":"https://www.federalregister.gov/documents/2024/04/26/2024-07773/pfas-national-primary-drinking-water-regulation"},{"id":"stockholm_pops_pfas","type":"regulatory","title":"Stockholm Convention decision SC-12/12 (2025): long-chain perfluorocarboxylic acids, their salts and related compounds listed in Annex A, defined as CnF2n+1COOH with 8 ≤ n ≤ 20; PFNA is C9 (n = 8).","year":2025,"url":"https://www.pops.int/Portals/0/download.aspx?d=UNEP-POPS-COP.12-SC-12-12.English.pdf"},{"id":"r60-2026-09-26-d867-cc2-ecfr-40cfr141.61","type":"regulatory","title":"§ 141.61 Maximum contaminant levels for organic contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-40.xml?part=141&section=141.61"},{"id":"r60-2026-09-28-d899-s2-b02-epa-npdwr-table","type":"regulatory","title":"National Primary Drinking Water Regulations | US EPA","url":"https://www.epa.gov/ground-water-and-drinking-water/national-primary-drinking-water-regulations"},{"id":"r60-2026-09-28-d899-s2-b03-epa-pfas-npdwr","type":"regulatory","title":"Per- and Polyfluoroalkyl Substances (PFAS) | US EPA","url":"https://www.epa.gov/sdwa/and-polyfluoroalkyl-substances-pfas"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-10-01-dd54-pops-new-pops","type":"regulatory","title":"Stockholm Convention: The New POPs (the Convention's own index of listed chemicals)","url":"https://www.pops.int/TheConvention/ThePOPs/TheNewPOPs/tabid/2511/Default.aspx"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-haz-map-information-on-hazardous-chemica-cid-67821","type":"database","title":"Haz-Map, Information on Hazardous Chemicals and Occupational Diseases, as recorded by PubChem (Experimental Properties, CID 67821; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/67821/JSON?heading=Experimental+Properties"},{"id":"doc-2026-10-02-d975-www-atsdr-cdc-gov-toxprofiles-tp200-pdf","type":"assessment","title":"Toxicological Profile for Perfluoroalkyls (ATSDR, Released May 2021)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp200.pdf"},{"id":"ctx_pred_dtxsid8031863","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID8031863 (PFNA (Perfluorononanoic acid))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID8031863"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:ECHA (CLP Annex VI):eye irritation: eye dam. 1","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":49,"warnings":["unmapped_classification:IARC:not evaluated by iarc","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:ECHA (CLP Annex VI):eye irritation: eye dam. 1"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}