{"hq_id":"hq-c-org-000109","name":"Methotrexate","context":"human_adult","timestamp":"2026-08-28T01:29:12.879Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.370827,"weightedMean":0.370827,"std_dev":0.112191,"confidence_interval_95":[0.475,0.475],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.475,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.25,"weight":0.30176}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.25206,"disagreement_magnitude":0.366428,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (48th percentile), while EPA CTX / IARC concludes lower risk (25th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_suppl7_methotrexate","type":"regulatory","title":"IARC Monographs Supplement 7 (1987): Methotrexate — Group 3 (Not classifiable as to its carcinogenicity to humans)","year":1987,"url":"https://inchem.org/documents/iarc/suppl7/methotrexate.html"},{"id":"fda_methotrexate_prescribing","type":"regulatory","title":"US FDA: Methotrexate Prescribing Information — Indications, Dosing, Black Box Warnings (Myelosuppression, Hepatotoxicity, Pulmonary Toxicity, Teratogenicity), and Leucovorin Rescue","year":2022}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 16 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 16 positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":48,"warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 16 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 16 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","dog","cat","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}