{"hq_id":"hq-c-org-000104","name":"1,4-Dioxane","context":"human_adult","timestamp":"2026-06-17T20:27:56.847Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.58481,"weightedMean":0.58481,"std_dev":0.181454,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"IARC","year":1999,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.752744,"weightedMean":0.752744,"std_dev":0.130378,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1999,"value":0.82,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.53333,"weightedMean":0.53333,"std_dev":0.246789,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.936948,"weightedMean":0.936948,"std_dev":0.12223,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1999,"value":1,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.78573,"weightedMean":0.78573,"std_dev":0.069264,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1999,"value":0.75,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.319781,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA:likely carcinogenic to humans (group b2 under olde","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 3 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3b (category 3) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":46,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA:likely carcinogenic to humans (group b2 under olde","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 3 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3b (category 3) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}