{"hq_id":"hq-c-org-000091","name":"Perfluorooctane sulfonic acid (PFOS)","context":"human_adult","timestamp":"2026-10-27T20:52:50.550Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000091","sha256":"d85a9ea1cb2613aa5313b325fc974e86fb4a79049ff19d3a34047509a1f2727d"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.562871,"weightedMean":0.562871,"std_dev":0.165304,"confidence_interval_95":[0.35,0.75],"source_positions":[{"source":"US EPA","year":2024,"value":0.75,"weight":0.5494},{"source":"IARC","year":2023,"value":0.5,"weight":0.45018},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.737011,"weightedMean":0.737011,"std_dev":0.140247,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2023,"value":0.82,"weight":0.45018},{"source":"US EPA","year":2024,"value":0.82,"weight":0.5494}]},"recency":{"mean":0.71522,"weightedMean":0.71522,"std_dev":0.176298,"confidence_interval_95":[0.549,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2023,"value":0.549,"weight":0.45018},{"source":"US EPA","year":2024,"value":0.67,"weight":0.5494}]},"methodology":{"mean":0.922198,"weightedMean":0.922198,"std_dev":0.131482,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2023,"value":1,"weight":0.45018},{"source":"US EPA","year":2024,"value":1,"weight":0.5494}]},"specificity":{"mean":0.794088,"weightedMean":0.794088,"std_dev":0.074506,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2023,"value":0.75,"weight":0.45018},{"source":"US EPA","year":2024,"value":0.75,"weight":0.5494}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.299066,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_pfos_vol135_2023","type":"regulatory","title":"IARC Monographs Volume 135: Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonic Acid (PFOS) — Group 1/2B Evaluation: PFOA classified Group 1 (carcinogenic to humans), PFOS classified Group 2B (possibly carcinogenic to humans)","year":2023,"url":"https://www.ncbi.nlm.nih.gov/books/NBK614282/"},{"id":"epa_pfas_mclg_2024","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulation for PFAS — Maximum Contaminant Level Goals and MCLs for PFOA, PFOS, and Four Other PFAS (Final Rule)","year":2024,"url":"https://www.federalregister.gov/documents/2024/04/26/2024-07773/pfas-national-primary-drinking-water-regulation"},{"id":"epa_pfas_roadmap_2021","type":"regulatory","title":"US EPA: PFAS Strategic Roadmap — EPA's Commitments to Action 2021–2024 (PFOS/PFOA Priority Designation and Regulatory Framework)","year":2021},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"src_pubchem_tox_74483","type":"pubchem","title":"PubChem: Toxicity section (CID 74483)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/74483/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-74483","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 74483; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/74483/JSON?heading=Experimental+Properties"},{"id":"doc-2026-10-02-d975-www-atsdr-cdc-gov-toxprofiles-tp200-pdf","type":"assessment","title":"Toxicological Profile for Perfluoroalkyls (ATSDR, Released May 2021)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp200.pdf"},{"id":"ctx_pred_dtxsid3031864","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3031864 (Perfluorooctane sulfonic acid (PFOS))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3031864"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":49,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","aquatic_life","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}