{"hq_id":"hq-c-org-000091","name":"Perfluorooctane sulfonic acid (PFOS)","context":"human_adult","timestamp":"2026-08-28T02:47:17.211Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.562871,"weightedMean":0.562871,"std_dev":0.165304,"confidence_interval_95":[0.5,0.75],"source_positions":[{"source":"US EPA","year":2024,"value":0.75,"weight":0.5494},{"source":"IARC","year":2023,"value":0.5,"weight":0.45018},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.737011,"weightedMean":0.737011,"std_dev":0.140247,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2023,"value":0.82,"weight":0.45018},{"source":"US EPA","year":2024,"value":0.82,"weight":0.5494}]},"recency":{"mean":0.71522,"weightedMean":0.71522,"std_dev":0.176298,"confidence_interval_95":[0.67,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2023,"value":0.549,"weight":0.45018},{"source":"US EPA","year":2024,"value":0.67,"weight":0.5494}]},"methodology":{"mean":0.922198,"weightedMean":0.922198,"std_dev":0.131482,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2023,"value":1,"weight":0.45018},{"source":"US EPA","year":2024,"value":1,"weight":0.5494}]},"specificity":{"mean":0.794088,"weightedMean":0.794088,"std_dev":0.074506,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2023,"value":0.75,"weight":0.45018},{"source":"US EPA","year":2024,"value":0.75,"weight":0.5494}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.299066,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_pfos_vol135_2023","type":"regulatory","title":"IARC Monographs Volume 135: Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonic Acid (PFOS) — Group 1/2B Evaluation: PFOA classified Group 1 (carcinogenic to humans), PFOS classified Group 2B (possibly carcinogenic to humans)","year":2023},{"id":"epa_pfas_mclg_2024","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulation for PFAS — Maximum Contaminant Level Goals and MCLs for PFOA, PFOS, and Four Other PFAS (Final Rule)","year":2024},{"id":"epa_pfas_roadmap_2021","type":"regulatory","title":"US EPA: PFAS Strategic Roadmap — EPA's Commitments to Action 2021–2024 (PFOS/PFOA Priority Designation and Regulatory Framework)","year":2021}],"sources_scope":"context","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":45,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","aquatic_life","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}