{"hq_id":"hq-c-org-000091","name":"Perfluorooctane sulfonic acid (PFOS)","context":"human_adult","timestamp":"2026-05-01T15:30:45.185Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.546909,"weightedMean":0.546909,"std_dev":0.173623,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"IARC","year":2023,"value":0.7,"weight":0.45018},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.680031,"weightedMean":0.680031,"std_dev":0.158741,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2023,"value":0.82,"weight":0.45018}]},"recency":{"mean":0.746268,"weightedMean":0.746268,"std_dev":0.223726,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2023,"value":0.549,"weight":0.45018}]},"methodology":{"mean":0.86878,"weightedMean":0.86878,"std_dev":0.14882,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2023,"value":1,"weight":0.45018}]},"specificity":{"mean":0.824358,"weightedMean":0.824358,"std_dev":0.084331,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2023,"value":0.75,"weight":0.45018}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.330817,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[],"warnings":["unmapped_classification:US EPA:likely carcinogenic to humans (pfas class finding)","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","limited_synthesis"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":2,"db_version":45,"warnings":["unmapped_classification:US EPA:likely carcinogenic to humans (pfas class finding)","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)"]},"schema":"synthesis"}