{"hq_id":"hq-c-org-000084","name":"Benzyl butyl phthalate (BBP)","context":"human_adult","timestamp":"2026-09-10T11:39:16.399Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.450554,"weightedMean":0.450554,"std_dev":0.070512,"confidence_interval_95":[0.35,0.5],"source_positions":[{"source":"IARC","year":2021,"value":0.5,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2021,"value":0.82,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2021,"value":0.5,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2021,"value":1,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2021,"value":0.75,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.52992,"disagreement_magnitude":0.314261,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_73_bbp","type":"regulatory","title":"IARC Monographs Volume 142: Butyl Benzyl Phthalate — Evaluation of Carcinogenic Risks to Humans (Group 2B; supersedes the Volume 73 Group 3 evaluation)","year":2000},{"id":"reach_bbp_svhc","type":"regulatory","title":"ECHA/EU REACH: Benzyl Butyl Phthalate — SVHC Identification, Reproductive Toxicant Category 1B, Annex XIV Authorization Required","year":2011},{"id":"epa_bbp_reg","type":"regulatory","title":"US EPA: Benzyl Butyl Phthalate — IRIS Toxicological Review and Health Effects Assessment","year":2001}],"sources_scope":"context","warnings":["year_inferred:IARC:2021","year_inferred:EPA CTX / IRIS:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 3 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3b (category 3) (score"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":48,"warnings":["year_inferred:IARC:2021","year_inferred:EPA CTX / IRIS:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 3 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3b (category 3) (score"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","human_child","human_teen","human_elderly","human_infant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}