{"hq_id":"hq-c-org-000084","name":"Benzyl butyl phthalate (BBP)","context":"human_adult","timestamp":"2026-10-27T20:58:03.399Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000084","sha256":"34c8eb309d47aa90e448b7d3bfa460bdbd7a39f712277eeed3c3808532798217"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.464328,"weightedMean":0.464328,"std_dev":0.063861,"confidence_interval_95":[0.35,0.5],"source_positions":[{"source":"IARC","year":2026,"value":0.5,"weight":0.82},{"source":"EPA CTX / IRIS","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2026,"value":0.82,"weight":0.82},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.870419,"weightedMean":0.870419,"std_dev":0.255155,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2026,"value":0.75,"weight":0.82},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.57426,"disagreement_magnitude":0.220817,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_73_bbp","type":"regulatory","title":"IARC Monographs Volume 142: Butyl Benzyl Phthalate — Evaluation of Carcinogenic Risks to Humans (Group 2B; supersedes the Volume 73 Group 3 evaluation)","year":2000},{"id":"reach_bbp_svhc","type":"regulatory","title":"ECHA/EU REACH: Benzyl Butyl Phthalate — SVHC Identification, Reproductive Toxicant Category 1B, Annex XIV Authorization Required","year":2011},{"id":"epa_bbp_reg","type":"regulatory","title":"US EPA: Benzyl Butyl Phthalate — IRIS Toxicological Review and Health Effects Assessment","year":2001},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-30-d918-iris-landing-293-butyl-benzyl-phthalate-bbp","type":"regulatory","title":"Butyl benzyl phthalate (BBP) | CASRN 85-68-7 | DTXSID3020205 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=293"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_2347","type":"pubchem","title":"PubChem: Toxicity section (CID 2347)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/2347/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d968-echa-candidate-list-xml","type":"regulatory","title":"ECHA Candidate List export (XML, operator-saved 2026-10-02)","url":"https://echa.europa.eu/candidate-list-table"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-2347","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 2347; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/2347/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid3020205","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3020205 (Benzyl butyl phthalate (BBP))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3020205"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / IRIS:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":51,"warnings":["year_inferred:EPA CTX / IRIS:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","human_child","human_teen","human_elderly","human_infant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}