{"hq_id":"hq-c-org-000083","name":"Dibutyl phthalate (DBP)","context":"human_adult","timestamp":"2026-10-27T20:53:00.627Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000083","sha256":"b53c99a3cb0cba44a1a8958038f1ce9a2966049a7e6d8fb6171f89420d59490a"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.455128,"weightedMean":0.455128,"std_dev":0.068683,"confidence_interval_95":[0.35,0.5],"source_positions":[{"source":"IARC","year":2026,"value":0.5,"weight":0.82},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2026,"value":0.82,"weight":0.82}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2026,"value":0.75,"weight":0.82}]},"consensus":{"exists":false,"strength":0.542113,"disagreement_magnitude":0.220817,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_73_dbp","type":"regulatory","title":"IARC Monographs Volume 142: Dibutyl Phthalate — Evaluation of Carcinogenic Risks to Humans (Group 2B; supersedes the Volume 73 Group 3 evaluation)","year":2000},{"id":"epa_dbp_reg","type":"regulatory","title":"US EPA: Dibutyl Phthalate — IRIS Toxicological Review and Reference Doses","year":2006},{"id":"reach_dbp_svhc","type":"regulatory","title":"ECHA/EU REACH: Dibutyl Phthalate — Substance of Very High Concern (SVHC) Identification, Reproductive Toxicant Category 1B, Annex XIV Restriction","year":2011},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-25-d449-iris-38","type":"regulatory","title":"Dibutyl phthalate (DBP) | CASRN 84-74-2 | DTXSID2021781 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=38"},{"id":"r60-2026-10-01-dd54-hc-trvs-v2-h128-1-11-638","type":"regulatory","title":"Federal Contaminated Site Risk Assessment in Canada, Part II: Health Canada Toxicological Reference Values (TRVs) and Chemical-Specific Factors, Version 2.0","url":"http://publications.gc.ca/collections/collection_2012/sc-hc/H128-1-11-638-eng.pdf"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_3026","type":"pubchem","title":"PubChem: Toxicity section (CID 3026)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3026/JSON?heading=Toxicity"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d968-echa-candidate-list-xml","type":"regulatory","title":"ECHA Candidate List export (XML, operator-saved 2026-10-02)","url":"https://echa.europa.eu/candidate-list-table"},{"id":"pubchem-exp-cameo-chemicals-cid-3026","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 3026; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3026/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid2021781","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID2021781 (Dibutyl phthalate (DBP))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID2021781"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Health Canada:group vi: cepa (unclassifiable with respect to car","unmapped_classification:EPA IRIS:group d not classifiable as to human carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: studies indicate no sign","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":50,"warnings":["unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Health Canada:group vi: cepa (unclassifiable with respect to car","unmapped_classification:EPA IRIS:group d not classifiable as to human carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: studies indicate no sign","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","human_child","aquatic_life","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}