{"hq_id":"hq-c-org-000083","name":"Dibutyl phthalate (DBP)","context":"human_adult","timestamp":"2026-09-10T09:51:34.341Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.430921,"weightedMean":0.430921,"std_dev":0.074766,"confidence_interval_95":[0.35,0.5],"source_positions":[{"source":"IARC","year":2021,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2021,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2021,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2021,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2021,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.50156,"disagreement_magnitude":0.314261,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_73_dbp","type":"regulatory","title":"IARC Monographs Volume 142: Dibutyl Phthalate — Evaluation of Carcinogenic Risks to Humans (Group 2B; supersedes the Volume 73 Group 3 evaluation)","year":2000},{"id":"epa_dbp_reg","type":"regulatory","title":"US EPA: Dibutyl Phthalate — IRIS Toxicological Review and Reference Doses","year":2006},{"id":"reach_dbp_svhc","type":"regulatory","title":"ECHA/EU REACH: Dibutyl Phthalate — Substance of Very High Concern (SVHC) Identification, Reproductive Toxicant Category 1B, Annex XIV Restriction","year":2011}],"sources_scope":"context","warnings":["year_inferred:IARC:2021","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Health Canada:group vi: cepa (unclassifiable with respect to car","unmapped_classification:EPA CTX / EPA OPP:group d not classifiable as to human carcinogenici","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: studies indicate no signi","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":47,"warnings":["year_inferred:IARC:2021","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / Health Canada:group vi: cepa (unclassifiable with respect to car","unmapped_classification:EPA CTX / EPA OPP:group d not classifiable as to human carcinogenici","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: studies indicate no signi","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","human_child","aquatic_life","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}