{"hq_id":"hq-c-org-000080","name":"Nicotine","context":"human_adult","timestamp":"2026-08-28T02:48:50.978Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low to moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"aspca_nicotine","type":"report","title":"ASPCA Animal Poison Control Center: Nicotine and E-Cigarette Liquid Toxicosis in Companion Animals","year":2022},{"id":"fda_ecig_safety","type":"regulatory","title":"US FDA: Liquid Nicotine — Safety Requirements for Child-Resistant Packaging and E-Cigarette Product Regulation","year":2021},{"id":"who_tobacco","type":"regulatory","title":"WHO: Tobacco and Health — Nicotine Pharmacology, Addiction, and Developmental Toxicity","year":2019}],"sources_scope":"context","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: severe irritation (score","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vitro / ex vivo: ambiguous (sco","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":47,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: severe irritation (score","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vitro / ex vivo: ambiguous (sco","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to "]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["dog","cat","human_adult","human_child","exposure_ingestion","exposure_dermal","human_teen","human_elderly","human_infant","human_pregnant"]}