{"hq_id":"hq-c-org-000079","name":"Microcystin-LR","context":"human_adult","timestamp":"2026-10-27T21:02:26.796Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000079","sha256":"fc540e0ab8d4ea01d30a573f3743403ff0b028cef1de1255561740cad4246589"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.567126,"weightedMean":0.567126,"std_dev":0.062329,"confidence_interval_95":[0.5,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.5,"weight":0.30176}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.584473,"disagreement_magnitude":0.356749,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (63th percentile), while EPA CTX / IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"epa_cyanotoxins_2015","type":"regulatory","title":"US EPA: Cyanotoxins in Drinking Water — Health Advisories for Microcystins and Cylindrospermopsin","year":2015},{"id":"who_microcystin","type":"regulatory","title":"WHO: Cyanobacterial Toxins — Microcystin-LR in Drinking Water: Background Document for Development of WHO Guidelines","year":2003},{"id":"iarc_microcystin_vol94","type":"regulatory","title":"IARC Monographs Volume 94 (2010): Microcystin-LR — Group 2B Evaluation (Possibly Carcinogenic to Humans)","year":2018},{"id":"r60-2026-09-26-d867-cc2-epa-drinking-water-health-advisories","type":"regulatory","title":"Drinking Water Health Advisories (HAs) | US EPA","url":"https://www.epa.gov/sdwa/drinking-water-health-advisories-has"},{"id":"r60-2026-09-27-d899-who-gdwq-4th-ed-addenda-2026-pdftotext","type":"regulatory","title":"Guidelines for drinking-water quality: fourth edition incorporating the first, second and third addenda","url":"https://iris.who.int/server/api/core/bitstreams/c60cc28e-defe-45ed-b157-71fdd43902bf/content"},{"id":"r60-2026-09-28-d899-s2-b03-epa-cyanotoxins-fact-sheet-2015","type":"regulatory","title":"2015 Drinking Water Health Advisories for Two Cyanobacterial Toxins","url":"https://www.epa.gov/sites/default/files/2017-06/documents/cyanotoxins-fact_sheet-2015.pdf"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"ctx_pred_dtxsid3031654","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3031654 (Microcystin-LR)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3031654"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / IARC:2021","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":47,"warnings":["year_inferred:EPA CTX / IARC:2021"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["dog","human_adult","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}