{"hq_id":"hq-c-org-000052","name":"Bis(chloromethyl) ether (BCME)","context":"human_adult","timestamp":"2026-05-01T19:53:30.144Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.782692,"weightedMean":0.782692,"std_dev":0.13275,"confidence_interval_95":[0.75,0.95],"source_positions":[{"source":"IARC","year":1987,"value":0.95,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1987,"value":0.82,"weight":0.41},{"source":"US EPA","year":2000,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"US EPA","year":2000,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1987,"value":1,"weight":0.41},{"source":"US EPA","year":2000,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1987,"value":0.75,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.115,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["Failed to vectorize source EPA CTX / NTP RoC: Source must have year field","Failed to vectorize source EPA CTX / CalEPA: Source must have year field","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:a (human carcinogen)","unmapped_classification:EPA CTX / IARC:group 1 - carcinogenic to humans","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":3,"db_version":49,"warnings":["Failed to vectorize source EPA CTX / NTP RoC: Source must have year field","Failed to vectorize source EPA CTX / CalEPA: Source must have year field","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:a (human carcinogen)","unmapped_classification:EPA CTX / IARC:group 1 - carcinogenic to humans","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ"]},"schema":"synthesis"}