{"hq_id":"hq-c-org-000045","name":"Methanol","context":"human_adult","timestamp":"2026-10-27T20:55:30.114Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000045","sha256":"dab7a17405961f0939d1961b36d13dc7b7c6c44d749187946808dd2bd73e160a"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.625,"weightedMean":0.625,"std_dev":0,"confidence_interval_95":[0.625,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"atsdr_methanol","type":"report","title":"Methanol Toxicity -- StatPearls (NCBI Bookshelf, NIH) -- source corrected: no ATSDR \"Toxicological Profile\" exists for methanol specifically (unlike lead/benzene/TCE, methanol is not on ATSDR's priority-substance Tox Profile list -- confirmed after searching ATSDR's own toxprofiles directory, ToxFAQs, and NCBI Bookshelf mirrors); this StatPearls clinical toxicology reference covers the same acute/chronic-effects content the record described","year":1999,"url":"https://www.ncbi.nlm.nih.gov/books/NBK482121/"},{"id":"cdc_methanol","type":"report","title":"CDC: Methanol Toxicity — Clinical and Emergency Response Guidance","year":2020,"url":"https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750029.html"},{"id":"epa_methanol_iris","type":"regulatory","title":"US EPA IRIS: Methanol — Reference Concentration and Toxicological Review","year":2013,"url":"https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0305tr.pdf"},{"id":"r60-2026-09-29-d899-s2-b07-iris-landing-305-methanol","type":"regulatory","title":"Methanol | CASRN 67-56-1 | DTXSID2021731 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-29-d899-s2-b07-iris-0305-summary-methanol","type":"regulatory","title":"Methanol; CASRN 67-56-1","url":"https://iris.epa.gov/static/pdfs/0305_summary.pdf"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_887","type":"pubchem","title":"PubChem: Toxicity section (CID 887)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/887/JSON?heading=Toxicity"},{"id":"r60-2026-09-29-d899-s1-b05-niosh-npg-npgd0397-methyl-alcohol","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards: Methyl alcohol (npgd0397)","url":"https://www.cdc.gov/niosh/npg/npgd0397.html"},{"id":"r60-2026-09-25-d897-eu-cellar-32006L0015","type":"regulatory","title":"L_2006038EN.01003601.xml","url":"https://publications.europa.eu/resource/celex/32006L0015"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid2021731","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID2021731 (Methanol)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID2021731"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:OSHA:pel 200 ppm","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Canada, as recorded by ToxValDB:eye irritation: serious eye damage/eye irritation ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":52,"warnings":["unmapped_classification:OSHA:pel 200 ppm","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Canada, as recorded by ToxValDB:eye irritation: serious eye damage/eye irritation ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","dog","cat","exposure_inhalation","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_ocular","occupational_exposure"]}