{"hq_id":"hq-c-org-000042","name":"Aspartame","context":"human_adult","timestamp":"2026-10-27T19:01:06.096Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000042","sha256":"c3f8bed7b0004f1d59b5bb87774b78fa662bb3d197fc5c1ffeea8930ca4b0c47"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.41252,"weightedMean":0.41252,"std_dev":0.099213,"confidence_interval_95":[0.3,0.5],"source_positions":[{"source":"IARC","year":2023,"value":0.5,"weight":0.45018},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.680031,"weightedMean":0.680031,"std_dev":0.158741,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2023,"value":0.82,"weight":0.45018}]},"recency":{"mean":0.746268,"weightedMean":0.746268,"std_dev":0.223726,"confidence_interval_95":[0.549,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2023,"value":0.549,"weight":0.45018}]},"methodology":{"mean":0.86878,"weightedMean":0.86878,"std_dev":0.14882,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2023,"value":1,"weight":0.45018}]},"specificity":{"mean":0.824358,"weightedMean":0.824358,"std_dev":0.084331,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2023,"value":0.75,"weight":0.45018}]},"consensus":{"exists":false,"strength":0.33858,"disagreement_magnitude":0.304861,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_134_aspartame","type":"regulatory","title":"IARC Monographs Volume 134: Aspartame and Other Sweeteners","year":2023},{"id":"jecfa_aspartame_2023","type":"regulatory","title":"WHO/FAO JECFA: Safety Assessment of Aspartame — 96th Meeting Report","year":2023},{"id":"fda_aspartame","type":"regulatory","title":"US FDA: Aspartame and Other Sweeteners in Food — FDA Response to IARC Classification","year":2023},{"id":"r60-2026-09-27-d899-s4-fda-aspartame-and-other-sweeteners-in-food","type":"regulatory","title":"Aspartame and Other Sweeteners in Food | FDA","url":"https://www.fda.gov/food/food-additives-petitions/aspartame-and-other-sweeteners-food"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"ctx_pred_dtxsid0020107","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID0020107 (Aspartame)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID0020107"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":49,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","dog","cat","human_teen","human_elderly","human_infant","human_pregnant"]}