{"hq_id":"hq-c-org-000035","name":"Acrolein","context":"human_adult","timestamp":"2026-10-27T18:50:46.707Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000035","sha256":"ddb0afc0b5fceff9251e7a9e65bcc2d7698372266439b1635024b77af788ebe2"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.527784,"weightedMean":0.527784,"std_dev":0.148631,"confidence_interval_95":[0.35,0.7],"source_positions":[{"source":"IARC","year":2021,"value":0.7,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2021,"value":0.82,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2021,"value":0.5,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2021,"value":1,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2021,"value":0.75,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.009127,"disagreement_magnitude":0.344616,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_63_acrolein","type":"regulatory","title":"IARC Monographs Volume 63: Acrolein","year":1995},{"id":"epa_acrolein_iris","type":"regulatory","title":"US EPA IRIS: Acrolein — Provisional Toxicological Review (External Review Draft)","year":2003},{"id":"atsdr_acrolein","type":"report","title":"ATSDR Toxicological Profile for Acrolein","year":2007},{"id":"r60-2026-09-25-d449-iris-364","type":"regulatory","title":"Acrolein | CASRN 107-02-8 | DTXSID5020023 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=364"},{"id":"r60-2026-09-24-d867-niosh-npg-npgd0011","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Acrolein","url":"https://www.cdc.gov/niosh/npg/npgd0011.html"},{"id":"r60-2026-09-25-d867-ecfr-29cfr1926-subpartD","type":"regulatory","title":"Subpart D—Occupational Health and Environmental Controls","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-29.xml?part=1926&subpart=D"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-09-30-d907-f1d6179110","type":"regulatory","title":"Industry Code of Practice on Chemicals Classification and Hazard Communication (DOSH Malaysia)","url":"https://dosh.gov.my/wp-content/uploads/2026/06/ICOP-Chemical-Classification-and-Hazard-Communication-2014.pdf"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_7847","type":"pubchem","title":"PubChem: Toxicity section (CID 7847)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7847/JSON?heading=Toxicity"},{"id":"r60-2026-10-03-d928-cellar-32017l0164","type":"regulatory","title":"L_2017027EN.01011501.xml","url":"https://publications.europa.eu/resource/celex/32017L0164"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-7847","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 7847; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7847/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid5020023","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID5020023 (Acrolein)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID5020023"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:US EPA:data are inadequate for an assessment of human car","unmapped_classification:EPA CTX / IRIS:data are inadequate for an assessment of human car","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin corr. 1b","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 1 (score: very high)","unmapped_classification:DOSH Malaysia (ICOP):eye irritation: eye dam. 1","unmapped_classification:DOSH Malaysia (ICOP):skin irritation: skin corr. 1b","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2c (category 1c) (scor"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":52,"warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:US EPA:data are inadequate for an assessment of human car","unmapped_classification:EPA CTX / IRIS:data are inadequate for an assessment of human car","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin corr. 1b","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 1 (score: very high)","unmapped_classification:DOSH Malaysia (ICOP):eye irritation: eye dam. 1","unmapped_classification:DOSH Malaysia (ICOP):skin irritation: skin corr. 1b","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2c (category 1c) (scor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_ingestion","exposure_ocular","occupational_exposure"]}