{"hq_id":"hq-c-org-000035","name":"Acrolein","context":"human_adult","timestamp":"2026-05-01T15:14:44.416Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.244872,"weightedMean":0.244872,"std_dev":0.080433,"confidence_interval_95":[0.25,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35},{"source":"IARC","year":1995,"value":0.25,"weight":0.41},{"source":"US EPA","year":2003,"value":0.15,"weight":0.41}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1995,"value":0.82,"weight":0.41},{"source":"US EPA","year":2003,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1995,"value":0.5,"weight":0.41},{"source":"US EPA","year":2003,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1995,"value":1,"weight":0.41},{"source":"US EPA","year":2003,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1995,"value":0.75,"weight":0.41},{"source":"US EPA","year":2003,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.46378,"disagreement_magnitude":0.310258,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (35th percentile), while US EPA concludes lower risk (15th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["unmapped_classification:EPA CTX / IRIS:data are inadequate for an assessment of human car","unmapped_classification:EPA CTX / IARC:group 2a - probably carcinogenic to humans","unmapped_classification:EPA CTX / EPA OPP:group c possible human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corr. 1b (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corr. 1b (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 8.2c (category 1c) (scor"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":3,"db_version":49,"warnings":["unmapped_classification:EPA CTX / IRIS:data are inadequate for an assessment of human car","unmapped_classification:EPA CTX / IARC:group 2a - probably carcinogenic to humans","unmapped_classification:EPA CTX / EPA OPP:group c possible human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corr. 1b (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corr. 1b (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 8.2c (category 1c) (scor"]},"schema":"synthesis"}