{"hq_id":"hq-c-org-000034","name":"Acrylonitrile","context":"human_adult","timestamp":"2026-10-27T17:10:16.622Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000034","sha256":"2a23b0abaf05b3c186dd93115929b41af86d9461ea8ca9e14ba225798b19c513"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.787088,"weightedMean":0.787088,"std_dev":0.127926,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2025,"value":0.95,"weight":0.67158},{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2014,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.764966,"weightedMean":0.764966,"std_dev":0.120757,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2025,"value":0.82,"weight":0.67158},{"source":"US EPA","year":2014,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.652115,"weightedMean":0.652115,"std_dev":0.242084,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2025,"value":0.819,"weight":0.67158},{"source":"US EPA","year":2014,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.948405,"weightedMean":0.948405,"std_dev":0.113209,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2025,"value":1,"weight":0.67158},{"source":"US EPA","year":2014,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.779237,"weightedMean":0.779237,"std_dev":0.064152,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2025,"value":0.75,"weight":0.67158},{"source":"US EPA","year":2014,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.14716,"disagreement_magnitude":0.268211,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_71_acrylonitrile","type":"regulatory","title":"IARC Monographs Volume 71: Acrylonitrile","year":1999},{"id":"epa_acrylonitrile_iris","type":"regulatory","title":"US EPA IRIS: Acrylonitrile — Carcinogenicity Assessment (Final)","year":2014},{"id":"atsdr_acrylonitrile","type":"report","title":"ATSDR Toxicological Profile for Acrylonitrile","year":1990},{"id":"r60-2026-09-29-d899-s1-b07x-niosh-npg-npgd0014-acrylonitrile","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Acrylonitrile","url":"https://www.cdc.gov/niosh/npg/npgd0014.html"},{"id":"r60-2026-09-25-d867-ecfr-29cfr1926-subpartD","type":"regulatory","title":"Subpart D—Occupational Health and Environmental Controls","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-29.xml?part=1926&subpart=D"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1045","type":"regulatory","title":"§ 1910.1045 Acrylonitrile.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1045"},{"id":"r60-2026-09-29-d899-s1-b07x-ecfr-29cfr1926.1145","type":"regulatory","title":"§ 1926.1145 Acrylonitrile.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1926&section=1926.1145"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-ntp-roc-15th-listed-substances","type":"regulatory","title":"Substances Listed in the Fifteenth Report on Carcinogens","url":"https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf"},{"id":"r60-2026-09-25-d449-iris-206","type":"regulatory","title":"Acrylonitrile | CASRN 107-13-1 | DTXSID5020029 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=206"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_7855","type":"pubchem","title":"PubChem: Toxicity section (CID 7855)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7855/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d907-f1d6179110","type":"regulatory","title":"Industry Code of Practice on Chemicals Classification and Hazard Communication (DOSH Malaysia)","url":"https://dosh.gov.my/wp-content/uploads/2026/06/ICOP-Chemical-Classification-and-Hazard-Communication-2014.pdf"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"pubchem-exp-cameo-chemicals-cid-7855","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 7855; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7855/JSON?heading=Experimental+Properties"},{"id":"r60-2026-09-27-d867-cc1-ich-m7-r2-addendum-pdftotext","type":"regulatory","title":"Application of the principles of the ICH M7 guideline to calculation of compound-specific acceptable intakes: Addendum to M7(R2) (final version, adopted 3 April 2023)","url":"https://database.ich.org/sites/default/files/ICH_M7(R2)_Addendum_Step4_2023_0216.pdf"},{"id":"ctx_pred_dtxsid5020029","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID5020029 (Acrylonitrile)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID5020029"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):eye irritation: eye dam. 1","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin irrit. 2","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)","unmapped_classification:Canada, as recorded by ToxValDB:eye irritation: serious eye damage/eye irritation ","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:DOSH Malaysia (ICOP):eye irritation: eye dam. 1","unmapped_classification:DOSH Malaysia (ICOP):skin irritation: skin irrit. 2","unmapped_classification:DOSH Malaysia (ICOP):skin sensitization: skin sens. 1","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3a (category 2) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: corrosive or irritation p","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: severe irritation (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): low to mod"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":50,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP 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1","unmapped_classification:DOSH Malaysia (ICOP):skin irritation: skin irrit. 2","unmapped_classification:DOSH Malaysia (ICOP):skin sensitization: skin sens. 1","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3a (category 2) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: corrosive or irritation p","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: severe irritation (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): low to mod"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","exposure_dermal","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_ingestion","exposure_ocular","occupational_exposure"]}