{"hq_id":"hq-c-org-000034","name":"Acrylonitrile","context":"human_adult","timestamp":"2026-05-01T19:46:45.330Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.625,"weightedMean":0.625,"std_dev":0.104646,"confidence_interval_95":[0.625,0.75],"source_positions":[{"source":"US EPA","year":2014,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1999,"value":0.82,"weight":0.41},{"source":"US EPA","year":2014,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41},{"source":"US EPA","year":2014,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1999,"value":1,"weight":0.41},{"source":"US EPA","year":2014,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1999,"value":0.75,"weight":0.41},{"source":"US EPA","year":2014,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.30236,"disagreement_magnitude":0.312066,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (75th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["Failed to vectorize source EPA CTX / NTP RoC: Source must have year field","Failed to vectorize source EPA CTX / CalEPA: Source must have year field","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:b1 (probable human carcinogen - based on limited e","unmapped_classification:EPA CTX / IARC:group 2b - possibly carcinogenic to humans","unmapped_classification:EPA CTX / EPA OPP:group b1 probable human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 21 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 21 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - 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based on limited e","unmapped_classification:EPA CTX / IARC:group 2b - possibly carcinogenic to humans","unmapped_classification:EPA CTX / EPA OPP:group b1 probable human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 21 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 21 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - 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