{"hq_id":"hq-c-org-000028","name":"Acetaldehyde","context":"human_adult","timestamp":"2026-08-28T02:50:40.658Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.719383,"weightedMean":0.719383,"std_dev":0.15643,"confidence_interval_95":[0.65,0.95],"source_positions":[{"source":"EPA CTX / IARC","year":2021,"value":0.95,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":1991,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.475,"weight":0.35}]},"confidence":{"mean":0.752744,"weightedMean":0.752744,"std_dev":0.130378,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"US EPA","year":1991,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.53333,"weightedMean":0.53333,"std_dev":0.246789,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"US EPA","year":1991,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.936948,"weightedMean":0.936948,"std_dev":0.12223,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"US EPA","year":1991,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.78573,"weightedMean":0.78573,"std_dev":0.069264,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"US EPA","year":1991,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.330734,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (48th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_100e","type":"regulatory","title":"IARC Monographs Volume 100E: Personal Habits and Indoor Combustions — Acetaldehyde Associated with Consumption of Alcoholic Beverages","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304390/"},{"id":"epa_acetaldehyde_iris","type":"regulatory","title":"US EPA IRIS: Acetaldehyde — Carcinogenicity Assessment (Group B2)","year":1991,"url":"https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=290"},{"id":"ipcs_icsc_acetaldehyde","type":"report","title":"IPCS/ILO International Chemical Safety Card (ICSC 0009) — Acetaldehyde","url":"https://inchem.org/documents/icsc/icsc/eics0009.htm"}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 46 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 46 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":51,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 46 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 46 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","exposure_ingestion","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_ocular","occupational_exposure"]}