{"hq_id":"hq-c-org-000028","name":"Acetaldehyde","context":"human_adult","timestamp":"2026-06-17T13:07:45.776Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.719383,"weightedMean":0.719383,"std_dev":0.15643,"confidence_interval_95":[0.65,0.95],"source_positions":[{"source":"EPA CTX / IARC","year":2021,"value":0.95,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":1991,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.475,"weight":0.35}]},"confidence":{"mean":0.752744,"weightedMean":0.752744,"std_dev":0.130378,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"US EPA","year":1991,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.53333,"weightedMean":0.53333,"std_dev":0.246789,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"US EPA","year":1991,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.936948,"weightedMean":0.936948,"std_dev":0.12223,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"US EPA","year":1991,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.78573,"weightedMean":0.78573,"std_dev":0.069264,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"US EPA","year":1991,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.330734,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (48th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:b2 (probable human carcinogen - based on sufficien","unmapped_classification:EPA CTX / EPA OPP:group b2 probable human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 46 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 46 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":51,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:b2 (probable human carcinogen - based on sufficien","unmapped_classification:EPA CTX / EPA OPP:group b2 probable human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 46 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 46 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}