{"hq_id":"hq-c-org-000024","name":"Permethrin","context":"human_adult","timestamp":"2026-10-27T20:54:59.905Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000024","sha256":"b7c3e6efda3f3a71c66ececb2e4fc4f7da8282b6f3547d3f9dac4115b2eb59cc"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.410256,"weightedMean":0.410256,"std_dev":0.137365,"confidence_interval_95":[0.2,0.5],"source_positions":[{"source":"EPA CTX / EPA OPP","year":2026,"value":0.5,"weight":0.82},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2026,"value":0.82,"weight":0.82}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2026,"value":1,"weight":0.82}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2026,"value":1,"weight":0.82}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2026,"value":0.75,"weight":0.82}]},"consensus":{"exists":false,"strength":0.084233,"disagreement_magnitude":0.24952,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / EPA OPP classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"epa_permethrin_2006","type":"regulatory","title":"EPA: Permethrin Reregistration Eligibility Decision (RED)","year":2006},{"id":"r60-2026-09-28-d449-fr-2026-15634-91FR48772-raw","type":"regulatory","title":"Permethrin; Pesticide Tolerances","url":"https://www.federalregister.gov/documents/full_text/text/2026/08/03/2026-15634.txt"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"src_pubchem_tox_40326","type":"pubchem","title":"PubChem: Toxicity / Non-Human Toxicity Values (CID 40326)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/40326/JSON?heading=Toxicity"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-ilo-who-international-chemical-safety-ca-cid-40326","type":"database","title":"ILO-WHO International Chemical Safety Cards (ICSCs), as recorded by PubChem (Experimental Properties, CID 40326; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/40326/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid8022292","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID8022292 (Permethrin)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID8022292"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:IARC:group 3 (not classifiable)","unmapped_classification:US EPA:not classified as carcinogenic","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:US_EPA:registered","unmapped_classification:IARC:group_3","unmapped_classification:EU_REACH:approved","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":56,"warnings":["unmapped_classification:IARC:group 3 (not classifiable)","unmapped_classification:US EPA:not classified as carcinogenic","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:US_EPA:registered","unmapped_classification:IARC:group_3","unmapped_classification:EU_REACH:approved"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["cat","dog","human_adult","exposure_dermal","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"],"unsourced_values":["safety.dose_response.ld50"]}