{"hq_id":"hq-c-org-000020","name":"PFOA (Perfluorooctanoic acid)","context":"human_adult","timestamp":"2026-06-17T13:11:01.363Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.790593,"weightedMean":0.790593,"std_dev":0.119909,"confidence_interval_95":[0.75,0.95],"source_positions":[{"source":"IARC","year":2023,"value":0.95,"weight":0.45018},{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2016,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.745923,"weightedMean":0.745923,"std_dev":0.134971,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2023,"value":0.82,"weight":0.45018},{"source":"US EPA","year":2016,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.60399,"weightedMean":0.60399,"std_dev":0.226387,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2023,"value":0.549,"weight":0.45018},{"source":"US EPA","year":2016,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.930553,"weightedMean":0.930553,"std_dev":0.126536,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2023,"value":1,"weight":0.45018},{"source":"US EPA","year":2016,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.789353,"weightedMean":0.789353,"std_dev":0.071703,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2023,"value":0.75,"weight":0.45018},{"source":"US EPA","year":2016,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.200607,"disagreement_magnitude":0.325677,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: equivocal, 1 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: equivocal, 1 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irritation - category 2a (scor","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 8.2c (category 1c) (scor"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":51,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: equivocal, 1 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: equivocal, 1 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irritation - category 2a (scor","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 8.2c (category 1c) (scor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}