{"hq_id":"hq-c-org-000017","name":"Chlorpyrifos","context":"human_adult","timestamp":"2026-10-27T20:56:52.479Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000017","sha256":"41fdff0f45b32b0440084af5f785b933c8f9ef589a09c81e353ce3a4392a8120"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_chlorpyrifos_2021","type":"regulatory","title":"US EPA: Chlorpyrifos — Revocation of Food Tolerances","year":2021},{"id":"r60-2026-09-28-d449-fr-2017-06777-82FR16581-raw","type":"regulatory","title":"82 FR 16581 (2017-04-05) FR Doc 2017-06777: Chlorpyrifos; Order Denying PANNA and NRDC's Petition To Revoke Tolerances","url":"https://www.federalregister.gov/documents/full_text/text/2017/04/05/2017-06777.txt"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_2730","type":"pubchem","title":"PubChem: Toxicity section (CID 2730)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/2730/JSON?heading=Toxicity"},{"id":"r60-2026-10-03-d923-niosh-npgd0137","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Chlorpyrifos","url":"https://www.cdc.gov/niosh/npg/npgd0137.html"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-10-01-dd54-pops-new-pops","type":"regulatory","title":"Stockholm Convention: The New POPs (the Convention's own index of listed chemicals)","url":"https://www.pops.int/TheConvention/ThePOPs/TheNewPOPs/tabid/2511/Default.aspx"},{"id":"doc-2026-10-03-d975-www-atsdr-cdc-gov-toxprofiles-tp84-pdf","type":"assessment","title":"Toxicological Profile for Chlorpyrifos (ATSDR, September 1997)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp84.pdf"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"pubchem-computed-cid-2730","type":"database","title":"PubChem computed properties for CID 2730 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/2730"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d983-stockholm-convention-text-2025","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants: text with Annexes (2025 English)","url":"https://www.pops.int/Portals/0/download.aspx?e=UNEP-POPS-COP-CONVTEXT-2025.English.pdf"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"pubchem-exp-cameo-chemicals-cid-2730","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 2730; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/2730/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-2730","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 2730; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/2730/JSON?heading=Experimental+Properties"},{"id":"d974-o14-2026-10-03-d968-ecfr-40cfr180-s180.342","type":"regulatory","title":"40 CFR Part 180 (eCFR text as of 24 September 2026): § 180.342 Chlorpyrifos; tolerances for residues.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-25/title-40.xml?part=180"},{"id":"ctx_pred_dtxsid4020458","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID4020458 (Chlorpyrifos)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID4020458"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-2730","type":"database","title":"PubChem computed structure descriptors for CID 2730 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/2730"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score","unmapped_classification:US_EPA:banned_food_use","unmapped_classification:EU_REACH:banned","aggravating_only:negative_carcinogenicity_dropped:US EPA:human_adult","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":51,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score","unmapped_classification:US_EPA:banned_food_use","unmapped_classification:EU_REACH:banned","aggravating_only:negative_carcinogenicity_dropped:US EPA:human_adult"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","dog","cat","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}