{"hq_id":"hq-c-org-000017","name":"Chlorpyrifos","context":"human_adult","timestamp":"2026-06-21T08:15:35.336Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.219079,"weightedMean":0.219079,"std_dev":0.074766,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35},{"source":"US EPA","year":2021,"value":0.15,"weight":0.41}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"US EPA","year":2021,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"US EPA","year":2021,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"US EPA","year":2021,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"US EPA","year":2021,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.50156,"disagreement_magnitude":0.314261,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (30th percentile), while US EPA concludes lower risk (15th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[],"warnings":["year_inferred:US EPA:2021","unmapped_classification:EPA CTX / EPA OPP:group e evidence of non-carcinogenicity for humans","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3b (category 3) (score","unmapped_classification:US_EPA:banned_food_use","unmapped_classification:EU_REACH:banned","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":49,"warnings":["year_inferred:US EPA:2021","unmapped_classification:EPA CTX / EPA OPP:group e evidence of non-carcinogenicity for humans","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3b (category 3) (score","unmapped_classification:US_EPA:banned_food_use","unmapped_classification:EU_REACH:banned"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}