{"hq_id":"hq-c-org-000012","name":"PCBs (Polychlorinated Biphenyls)","context":"human_adult","timestamp":"2026-10-27T20:56:33.950Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000012","sha256":"a94561c06e09bdef22364b6ef738661e7b855d9ac552a597aaf2545a5c0eb30a"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.755486,"weightedMean":0.755486,"std_dev":0.12992,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2013,"value":0.95,"weight":0.41},{"source":"US EPA","year":1996,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2013,"value":0.82,"weight":0.41},{"source":"US EPA","year":1996,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.591841,"weightedMean":0.591841,"std_dev":0.233646,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2013,"value":0.5,"weight":0.41},{"source":"US EPA","year":1996,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2013,"value":1,"weight":0.41},{"source":"US EPA","year":1996,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2013,"value":0.75,"weight":0.41},{"source":"US EPA","year":1996,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.133867,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_107","type":"regulatory","title":"IARC Monographs Volume 107: Polychlorinated Biphenyls and Polybrominated Biphenyls","year":2013,"url":"https://www.ncbi.nlm.nih.gov/books/NBK361696/"},{"id":"epa_pcb","type":"regulatory","title":"US EPA: Polychlorinated Biphenyls (PCBs) — IRIS Assessment","year":1996,"url":"https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=294"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-ntp-roc-15th-listed-substances","type":"regulatory","title":"Substances Listed in the Fifteenth Report on Carcinogens","url":"https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf"},{"id":"r60-2026-09-25-d449-iris-294","type":"regulatory","title":"Polychlorinated Biphenyls (PCBs) | CASRN 1336-36-3 | DTXSID5024267 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=294"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Listing of POPs in the Stockholm Convention","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"doc-2026-10-02-d-975-s901-d975-tp17-pdf","type":"assessment","title":"Toxicological Profile for Polychlorinated Biphenyls (PCBs) (ATSDR, November 2000)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp17.pdf"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02008R1272-20260701","type":"regulatory","title":"Consolidated TEXT: 32008R1272 — EN — 01.07.2026 (Regulation (EC) No 1272/2008, CLP; the consolidation applicable on 2026-09-26)","url":"https://publications.europa.eu/resource/celex/02008R1272-20260701"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:Stockholm Convention:annex a (elimination) and annex c (unintentional p","unmapped_classification:Basel Convention:annex viii (y10) — hazardous-waste category for pc","unmapped_classification:ECHA:eu pops regulation 2019/1021 — pcb annex iv/v conc","unmapped_classification:Health Canada:cepa schedule 1 — polychlorinated biphenyls; pcb r","unmapped_classification:METI:pcb special measures law — japan","unmapped_classification:AICIS:australia national pcb management plan — phase-out"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":37,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:Stockholm Convention:annex a (elimination) and annex c (unintentional p","unmapped_classification:Basel Convention:annex viii (y10) — hazardous-waste category for pc","unmapped_classification:ECHA:eu pops regulation 2019/1021 — pcb annex iv/v conc","unmapped_classification:Health Canada:cepa schedule 1 — polychlorinated biphenyls; pcb r","unmapped_classification:METI:pcb special measures law — japan","unmapped_classification:AICIS:australia national pcb management plan — phase-out"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","aquatic_life","dog","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}