{"hq_id":"hq-c-org-000008","name":"Vinyl Chloride","context":"human_adult","timestamp":"2026-09-10T07:55:33.850Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.797089,"weightedMean":0.797089,"std_dev":0.110635,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":1979,"value":0.95,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1979,"value":0.82,"weight":0.41},{"source":"US EPA","year":2000,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1979,"value":0.5,"weight":0.41},{"source":"US EPA","year":2000,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1979,"value":1,"weight":0.41},{"source":"US EPA","year":2000,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1979,"value":0.75,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.262433,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":"No new angiosarcoma cases in US workers hired after 1975 standard (500-fold reduction in PEL from 500 to 1 ppm). Consumer exposure via VCM gas is now minimal.","warning":null},"sources":[{"id":"src_001","type":"iarc","title":"IARC Monographs Volume 100F - Vinyl Chloride","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304420/"},{"id":"src_002","type":"cdc","title":"ATSDR Toxicological Profile for Vinyl Chloride","year":2024,"url":"https://www.atsdr.cdc.gov/toxprofiles/tp20.pdf"},{"id":"src_003","type":"journal","title":"Sass et al. Vinyl Chloride: A Case Study of Data Suppression and Misrepresentation","year":2005,"url":"https://pubmed.ncbi.nlm.nih.gov/16002366/"},{"id":"src_004","type":"cdc","title":"MMWR - Angiosarcoma of the Liver Among Polyvinyl Chloride Workers - Kentucky 1974","url":"https://www.cdc.gov/mmwr/pdf/wk/mm4605.pdf"},{"id":"src_005","type":"epa","title":"EPA East Palestine, Ohio Train Derailment Response","url":"https://www.epa.gov/east-palestine-oh-train-derailment"},{"id":"src_006","type":"nih","title":"NIEHS East Palestine Train Derailment Research Response","url":"https://www.niehs.nih.gov/research/programs/east_palestine"},{"id":"src_007","type":"journal","title":"Mundt KA et al. (2017): Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide VC cohort (Occup Environ Med; PMID 28490663)","year":2017,"url":"https://pubmed.ncbi.nlm.nih.gov/28490663/"},{"id":"src_008","type":"vet","title":"Whole Dog Journal - The Dangers of Vinyl Dog Toys","url":"https://www.whole-dog-journal.com/care/dog-toys/the-dangers-of-vinyl-dog-toys/"},{"id":"src_009","type":"ngo","title":"Ecology Center - Pets Beware: Toxic Chemicals in Pet Food Cans","url":"https://www.ecocenter.org/our-work/healthy-stuff-lab/reports/pets-beware-toxic-chemicals-pet-food-cans-test-results/"},{"id":"src_010","type":"gov","title":"UK Government Vinyl Chloride Toxicological Overview","year":2024,"url":"https://www.gov.uk/government/publications/vinyl-chloride-properties-incident-management-and-toxicology/"}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 20 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 20 positiv","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":51,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 20 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 20 positiv","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","dog","cat","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_ingestion","exposure_ocular","occupational_exposure"]}