{"hq_id":"hq-c-org-000008","name":"Vinyl Chloride","context":"human_adult","timestamp":"2026-10-27T17:56:07.895Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000008","sha256":"62c1791f7b94407c5b22345022083df47d13ddf6cebbd17a8e17892708ebe459"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.797089,"weightedMean":0.797089,"std_dev":0.110635,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41},{"source":"US EPA","year":2000,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41},{"source":"US EPA","year":2000,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41},{"source":"US EPA","year":2000,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.262433,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":"No new angiosarcoma cases in US workers hired after 1975 standard (500-fold reduction in PEL from 500 to 1 ppm). Consumer exposure via VCM gas is now minimal.","warning":null},"sources":[{"id":"src_001","type":"iarc","title":"IARC Monographs Volume 100F - Vinyl Chloride","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304420/"},{"id":"src_002","type":"cdc","title":"ATSDR Toxicological Profile for Vinyl Chloride","year":2024,"url":"https://www.atsdr.cdc.gov/toxprofiles/tp20.pdf"},{"id":"src_003","type":"journal","title":"Sass et al. Vinyl Chloride: A Case Study of Data Suppression and Misrepresentation","year":2005,"url":"https://pubmed.ncbi.nlm.nih.gov/16002366/"},{"id":"src_004","type":"cdc","title":"MMWR - Angiosarcoma of the Liver Among Polyvinyl Chloride Workers - Kentucky 1974","url":"https://www.cdc.gov/mmwr/pdf/wk/mm4605.pdf"},{"id":"src_005","type":"epa","title":"EPA East Palestine, Ohio Train Derailment Response","url":"https://www.epa.gov/east-palestine-oh-train-derailment"},{"id":"src_006","type":"nih","title":"NIEHS East Palestine Train Derailment Research Response","url":"https://www.niehs.nih.gov/research/programs/east_palestine"},{"id":"src_007","type":"journal","title":"Mundt KA et al. (2017): Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide VC cohort (Occup Environ Med; PMID 28490663)","year":2017,"url":"https://pubmed.ncbi.nlm.nih.gov/28490663/"},{"id":"src_008","type":"vet","title":"Whole Dog Journal - The Dangers of Vinyl Dog Toys","url":"https://www.whole-dog-journal.com/care/dog-toys/the-dangers-of-vinyl-dog-toys/"},{"id":"src_009","type":"ngo","title":"Ecology Center - Pets Beware: Toxic Chemicals in Pet Food Cans","url":"https://www.ecocenter.org/our-work/healthy-stuff-lab/reports/pets-beware-toxic-chemicals-pet-food-cans-test-results/"},{"id":"src_010","type":"gov","title":"UK Government Vinyl Chloride Toxicological Overview","year":2024,"url":"https://www.gov.uk/government/publications/vinyl-chloride-properties-incident-management-and-toxicology/"},{"id":"r60-2026-09-24-d867-eu-reg-10-2011-consolidated-20260714","type":"regulatory","title":"Consolidated TEXT: 32011R0010 — EN — 14.07.2026","url":"https://publications.europa.eu/resource/celex/02011R0010-20260714"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-27-d903-ecfr-29cfr1910.1017","type":"regulatory","title":"§ 1910.1017 Vinyl chloride.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-29.xml?part=1910&section=1910.1017"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-24-d873-iris-landing-1001-vinyl-chloride","type":"regulatory","title":"Vinyl chloride | CASRN 75-01-4 | DTXSID8021434 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1001"},{"id":"r60-ntp-roc-15th-listed-substances","type":"regulatory","title":"Substances Listed in the Fifteenth Report on Carcinogens","url":"https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf"},{"id":"r60-2026-10-01-dd54-hc-trvs-v2-h128-1-11-638","type":"regulatory","title":"Federal Contaminated Site Risk Assessment in Canada, Part II: Health Canada Toxicological Reference Values (TRVs) and Chemical-Specific Factors, Version 2.0","url":"http://publications.gc.ca/collections/collection_2012/sc-hc/H128-1-11-638-eng.pdf"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_6338","type":"pubchem","title":"PubChem: Toxicity section (CID 6338)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6338/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-09-30-d899-s1-b10-niosh-npg-npgd0658-vinyl-chloride","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards: Vinyl chloride (npgd0658)","url":"https://www.cdc.gov/niosh/npg/npgd0658.html"},{"id":"doc-2026-09-30-d907-02d9dcdb8a","type":"assessment","title":"Toxicological Profile for Vinyl Chloride (ATSDR, January 2024)","url":"https://www.atsdr.cdc.gov/toxprofiles/tp20.pdf"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"doc-2026-10-03-d975-iris-epa-gov-static-pdfs-1001-summary-pdf","type":"assessment","title":"IRIS Chemical Assessment Summary: Vinyl chloride; 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as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/6338"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 2 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":54,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Health Canada:group i: cepa (carcinogenic to humans)","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 2 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","dog","cat","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_ingestion","exposure_ocular","occupational_exposure"]}