{"hq_id":"hq-c-mix-000084","name":"Histoplasma capsulatum","context":"human_adult","risk_level":"high","schema":"legacy","note":"Synthesis unavailable: compound lacks vectorizable regulatory classifications. Raw safety data returned.","data":{"risk_level":"high","summary":"Histoplasma capsulatum is a thermally dimorphic fungus (mold at 25C, yeast at 37C) and the causative agent of histoplasmosis, the most common endemic mycosis in the United States. Endemic regions: Ohio and Mississippi River valleys, Central America, parts of Africa and Asia. The fungus thrives in soil enriched with bird or bat guano — classic exposure settings include cave exploration (spelunkers), chicken coop cleaning, demolition of old buildings with bat roosts, and urban construction in endemic areas. Infection occurs via inhalation of microconidia (2-4 um). Most infections (95%) are asymptomatic or self-limited in immunocompetent individuals, causing only a positive histoplasmin skin test. Symptomatic acute pulmonary histoplasmosis resembles community-acquired pneumonia. Progressive disseminated histoplasmosis (PDH) occurs in immunocompromised patients (especially HIV/AIDS with CD4 <150): involves liver, spleen, bone marrow, adrenal glands, CNS; mortality 100% if untreated. WHO 2022 Fungal Priority Pathogens List: High priority. Treatment: mild — itraconazole; severe/disseminated — amphotericin B followed by itraconazole. Urine and serum antigen testing (Histoplasma galactomannan) is standard diagnostic.","source_refs":["aletheia_fungi_batch_2026"]},"meta":{"synthesis_version":"n/a","timestamp":"2026-05-01T14:23:20.121Z"}}