{"hq_id":"hq-c-mix-000068","name":"Diesel exhaust particulate (DEP)","context":"human_adult","timestamp":"2026-08-28T02:59:36.044Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.748259,"weightedMean":0.748259,"std_dev":0.128191,"confidence_interval_95":[0.65,0.95],"source_positions":[{"source":"IARC","year":2021,"value":0.95,"weight":0.41},{"source":"EPA","year":2021,"value":0.75,"weight":0.41},{"source":"NTP","year":2021,"value":0.65,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.749114,"weightedMean":0.749114,"std_dev":0.132886,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2021,"value":0.82,"weight":0.41},{"source":"NTP","year":2021,"value":0.82,"weight":0.41},{"source":"EPA","year":2021,"value":0.82,"weight":0.41}]},"recency":{"mean":0.610759,"weightedMean":0.610759,"std_dev":0.207634,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2021,"value":0.5,"weight":0.41},{"source":"NTP","year":2021,"value":0.5,"weight":0.41},{"source":"EPA","year":2021,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.933544,"weightedMean":0.933544,"std_dev":0.124581,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2021,"value":1,"weight":0.41},{"source":"NTP","year":2021,"value":1,"weight":0.41},{"source":"EPA","year":2021,"value":1,"weight":0.41}]},"specificity":{"mean":0.787658,"weightedMean":0.787658,"std_dev":0.070596,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2021,"value":0.75,"weight":0.41},{"source":"NTP","year":2021,"value":0.75,"weight":0.41},{"source":"EPA","year":2021,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.145393,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_diesel_exhaust_vol105_2014","type":"regulatory","title":"IARC Monographs Volume 105 (2014) + Volume 100E + Press Release 213 (June 2012) — Diesel Engine Exhaust reclassified Group 2A → Group 1 (Carcinogenic to Humans; sufficient evidence for lung cancer; limited evidence for bladder cancer)","year":2014,"url":"https://www.ncbi.nlm.nih.gov/books/NBK294269/"},{"id":"epa_diesel_exhaust_rfc_2002","type":"regulatory","title":"US EPA Health Assessment Document for Diesel Engine Exhaust — Reference Concentration (RfC) framework + IRIS hazard-identification (Likely to be carcinogenic to humans by inhalation)","year":2002,"url":"https://iris.epa.gov/static/pdfs/0642_summary.pdf"},{"id":"niosh_diesel_exhaust_pocket_guide","type":"regulatory","title":"NIOSH Current Intelligence Bulletin 50: Carcinogenic Effects of Exposure to Diesel Exhaust (DHHS/NIOSH Pub. 88-116)","year":1988,"url":"https://www.cdc.gov/niosh/docs/88-116/"},{"id":"msha_diesel_particulate_matter_pel","type":"regulatory","title":"MSHA 30 CFR 57.5060 — Limit on Diesel Particulate Matter (DPM) in metal/non-metal underground mines (160 µg/m³ TWA total carbon proxy)","year":2008,"url":"https://www.ecfr.gov/current/title-30/chapter-I/subchapter-K/part-57/subpart-D/subject-group-ECFR266136d1bf79d9f/section-57.5060"},{"id":"silverman_diesel_miner_cohort_2012","type":"study","title":"Silverman DT, Samanic CM, Lubin JH et al. — The Diesel Exhaust in Miners Study (DEMS): A nested case-control study of lung cancer and diesel exhaust (canonical IARC-105-driving NCI/NIOSH miner cohort, JNCI)","year":2012,"url":"https://pubmed.ncbi.nlm.nih.gov/22393209/"},{"id":"oehha_diesel_exhaust_prop65","type":"regulatory","title":"California OEHHA — Diesel Engine Exhaust Particulate listed under Proposition 65 (carcinogenicity 1990; reproductive toxicity 1998 — both endpoints)","year":1990,"url":"https://oehha.ca.gov/proposition-65/chemicals/diesel-engine-exhaust"}],"sources_scope":"record","warnings":["year_inferred:IARC:2021","year_inferred:NTP:2021","year_inferred:EPA:2021","unmapped_classification:CARB:toxic air contaminant (tac). diesel risk reduction","unmapped_classification:EU:emep/eea air pollutant inventories. euro vi emissi"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":4,"warnings":["year_inferred:IARC:2021","year_inferred:NTP:2021","year_inferred:EPA:2021","unmapped_classification:CARB:toxic air contaminant (tac). diesel risk reduction","unmapped_classification:EU:emep/eea air pollutant inventories. euro vi emissi"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","occupational","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}