{"hq_id":"hq-c-mix-000043","name":"Subtilisin (enzyme; detergent industry)","context":"human_adult","timestamp":"2026-10-27T20:04:22.167Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-mix-000043","sha256":"ce8625cd9abafbaf9d1dfaebd8a758dd33ae3372772f8ff5904c177e1cc04027"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"subtilisin_enzyme_occ","type":"regulatory","title":"Subtilisin Carlsberg Bacillus licheniformis Serine Protease; Enzyme Detergent Lung 1968-1970 Epidemic IgE Occupational Asthma 20-50% Workers; Encapsulation Prilled Granule Dust-Free; UK EU OEL 60 ng/m3 Enzyme Protein; Specific IgE Biological Monitoring Spirometry; Alcalase Savinase Esperase Protex Detergent Enzyme; 3 Billion Households Laundry; Consumer Low Risk Encapsulation; IARC Not Evaluated Biological Allergen","year":2020},{"id":"r60-2026-09-27-d867-cc1-hse-eh40-2005-fourth-edition-2020-pdftotext","type":"regulatory","title":"EH40/2005 Workplace exposure limits","url":"https://www.hse.gov.uk/pubns/priced/eh40.pdf"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not evaluated by iarc as carcinogenic — subtilisin","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":14,"warnings":["unmapped_classification:IARC:not evaluated by iarc as carcinogenic — subtilisin"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}