{"hq_id":"hq-c-mix-000039","name":"Catechol (tobacco smoke pyrolysate)","context":"human_adult","timestamp":"2026-08-28T04:08:15.477Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.535816,"weightedMean":0.535816,"std_dev":0.178081,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"IARC","year":1999,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1999,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1999,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1999,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.314261,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_catechol_1999","type":"regulatory","title":"IARC Monographs Volume 71 1999 Catechol Group 2B; Forestomach Tumors Rodents; Co-Carcinogen Tobacco Smoke PAH Synergy; o-Quinone DNA Adducts; COMT Oxidation; ACGIH TLV-TWA 5 ppm Skin; Skin Sensitizer; Pyrocatechol 1,2-Dihydroxybenzene; Coal Tar Phenolic","year":1999},{"id":"epa_catechol_iris","type":"regulatory","title":"US EPA IRIS — Catechol (1,2-Dihydroxybenzene; Group D Not Classifiable as to Human Carcinogenicity; oral-RfD framework; phenol-derivative metabolic-pathway profile)","year":2002},{"id":"echa_catechol_reach","type":"regulatory","title":"ECHA REACH Registration + CLP Notification — Catechol (Carc. 2 Suspected of causing cancer; Acute Tox. 4 inhalation/dermal/oral; Skin Sens. 1; Eye Dam. 1; Aquatic Acute 1)","year":2018},{"id":"niosh_catechol_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Catechol (REL 5 mg/m³ TWA; 'Ca' carcinogen designation; phenol-derivative manufacturing + dye-industry + photographic-developer cohort framework)","year":2019},{"id":"hirose_catechol_tobacco_cocarcinogen","type":"study","title":"Hirose M, Fukushima S, Sakata T et al. — Effects of catechol on the development of forestomach lesions in rats following initiation by N-methyl-N'-nitro-N-nitrosoguanidine (canonical IARC-71-driving co-carcinogen cohort framework)","year":1986}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 25 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 25 positiv"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":45,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 25 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 25 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}