{"hq_id":"hq-c-mix-000038","name":"Refractory Ceramic Fibers (RCF)","context":"human_adult","timestamp":"2026-08-28T04:04:03.896Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.430921,"weightedMean":0.430921,"std_dev":0.074766,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"IARC","year":2002,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2002,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2002,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2002,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2002,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.50156,"disagreement_magnitude":0.314261,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_rcf_2002","type":"regulatory","title":"IARC Monographs Volume 43 1988 Volume 81 2002 Refractory Ceramic Fibers Group 2B; Mesothelioma Rodents Intraperitoneal Inhalation; NTP Reasonably Anticipated Human Carcinogen; EU CLP Carc 1B H350i; Biopersistence Fiber Dimension WHO Criteria; GBP Granular Biopersistence Protocol; EU OEL 1 f/cm3; HTRFs High Temperature Resistant Fibers; Asbestos Comparison","year":2002},{"id":"osha_rcf_hazardous_substances","type":"regulatory","title":"OSHA Hazardous Substances List + 29 CFR 1910.1200 (HCS 2012) — Refractory Ceramic Fibers (aluminosilicate wool) GHS-classified Carc. 1B; ACGIH-driven 0.2 fiber/cc TLV adoption framework","year":2020},{"id":"acgih_rcf_tlv","type":"regulatory","title":"ACGIH TLV-TWA — Refractory Ceramic Fibers (0.2 fibers/cm³ respirable; A2 Suspected Human Carcinogen designation; furnace + kiln + insulation-installer cohort framework)","year":2024},{"id":"niosh_rcf_alert_1990","type":"regulatory","title":"NIOSH Hazard Review + Criteria Document — Occupational Exposure to Refractory Ceramic Fibers (REL 0.2 fibers/cm³ TWA; furnace + foundry + steel + petrochemical cohort framework)","year":2006},{"id":"lemasters_rcf_pleural_plaques_1994","type":"study","title":"Lemasters GK, Lockey JE, Levin LS et al. — Industry-wide pleural-plaque mortality study among RCF-manufacturing-cohort workers (canonical IARC-81-driving cohort framework)","year":1994}],"sources_scope":"record","warnings":["limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":12},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}