{"hq_id":"hq-c-mix-000034","name":"Hardwood Dust","context":"human_adult","timestamp":"2026-08-28T04:04:03.780Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.800329,"weightedMean":0.800329,"std_dev":0.161993,"confidence_interval_95":[0.95,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.339684,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_hardwood_dust_2012","type":"regulatory","title":"IARC Monographs Volume 62 1995 Volume 100C 2012 Hardwood Dusts Group 1; Nasal Adenocarcinoma ITAC Intestinal-Type Sinonasal; RR 40-900x Furniture Cabinet Workers; EU CLP Category 1A H350i; EU Binding OEL 1mg/m3 Inhalable; NTP Known Human Carcinogen; Latency 30-40 Years","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304376/"},{"id":"niosh_wood_dust_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Wood Dust (REL 1 mg/m³ TWA respirable; 'Ca' carcinogen designation; furniture + cabinet + carpenter cohort framework)","year":2019,"url":"https://www.cdc.gov/niosh/npg/npgd0667.html"},{"id":"osha_wood_dust_pel","type":"regulatory","title":"OSHA Table Z-1 — wood dust regulated as Particulates Not Otherwise Regulated: 15 mg/m³ total / 5 mg/m³ respirable (the 1989 wood-dust-specific 5 mg/m³ PEL was vacated, AFL-CIO v. OSHA 1992)","year":2020,"url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"acgih_wood_dust_tlv","type":"regulatory","title":"ACGIH TLV-TWA Wood Dust: 1 mg/m³ inhalable (0.5 western red cedar); carcinogen designation species-specific — A1 (oak, beech), A2 (birch, mahogany, teak, walnut), A4 (other woods). [proprietary ACGIH booklet — no free canonical URL]","year":2024},{"id":"demers_hardwood_sinonasal_cohort","type":"study","title":"Demers PA, Kogevinas M, Boffetta P et al. (1995): Wood dust and sino-nasal cancer — pooled reanalysis of twelve case-control studies (Am J Ind Med; PMID 8585514)","year":1995,"url":"https://pubmed.ncbi.nlm.nih.gov/8585514/"}],"sources_scope":"record","warnings":["limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":12},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}