{"hq_id":"hq-c-mix-000033","name":"Chromium(III) Compounds","context":"human_adult","timestamp":"2026-10-27T19:05:09.823Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-mix-000033","sha256":"3fcf71f6f1f4334fa716a8bc218c05479ac3e961d544549d93c12a01b5a5dcf3"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"iarc_chromium_iii_1990","type":"regulatory","title":"IARC Monographs Volume 49: Chromium, Nickel and Welding","year":1990,"url":"http://publications.iarc.fr/67"},{"id":"r60-2026-09-25-d449-iris-144","type":"regulatory","title":"Chromium(VI) | CASRN 18540-29-9 | DTXSID7023982 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=144"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-30-d918-iris-landing-28-chromium-iii-insoluble-salts","type":"regulatory","title":"Chromium(III), insoluble salts | CASRN 16065-83-1 | DTXSID2023981 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=28"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"doc-2026-09-30-d907-623b376147","type":"assessment","title":"Toxicological Profile for Chromium (ATSDR, September 2012)","url":"https://www.atsdr.cdc.gov/toxprofiles/tp7.pdf"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-human-metabolome-database-cid-27668","type":"database","title":"Human Metabolome Database (HMDB), as recorded by PubChem (Experimental Properties, CID 27668; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/27668/JSON?heading=Experimental+Properties"},{"id":"pubchem-computed-structure-cid-27668","type":"database","title":"PubChem computed structure descriptors for CID 27668 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/27668"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:group 3 — not classifiable as to carcinogenicity i","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":35,"warnings":["unmapped_classification:IARC:group 3 — not classifiable as to carcinogenicity i","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}