{"hq_id":"hq-c-mix-000030","name":"Pyrrolizidine alkaloids (hepatotoxic class)","context":"human_adult","timestamp":"2026-10-27T20:59:52.334Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-mix-000030","sha256":"f6b543e736929c651c9bd398abc457c5156bc7ff1f400e4bac628285823b7a6e"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.430921,"weightedMean":0.430921,"std_dev":0.074766,"confidence_interval_95":[0.35,0.5],"source_positions":[{"source":"IARC","year":2002,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2002,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2002,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2002,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2002,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.50156,"disagreement_magnitude":0.314261,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"efsa_pyrrolizidine_alkaloids_2017","type":"regulatory","title":"EFSA Panel on Contaminants in the Food Chain: Pyrrolizidine Alkaloids in Food and Feed — Occurrence, Exposure, Margin of Exposure, and Risk Characterization (EFSA Journal 2017;15(7):4829)","year":2017},{"id":"fda_pyrrolizidine_alkaloids_supplements","type":"regulatory","title":"US FDA: Pyrrolizidine Alkaloids in Dietary Supplements — Comfrey, Butterbur, Coltsfoot, and Related Hepatotoxic Herbs; Guidance and Warning Letters (2001, updated 2015)","year":2015},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EU:maximum limits for pas in certain food categories","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":17,"warnings":["unmapped_classification:EU:maximum limits for pas in certain food categories"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","dog","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}