{"hq_id":"hq-c-mix-000027","name":"Quantum dots (CdSe)","context":"human_adult","timestamp":"2026-10-27T21:22:21.745Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-mix-000027","sha256":"362bca8584aca318b823106dce4b1c0be032cf8d01960cd8cabd03f9ce01f15b"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.673684,"weightedMean":0.673684,"std_dev":0.299064,"confidence_interval_95":[0.35,0.95],"source_positions":[{"source":"IARC","year":2021,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2021,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2021,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2021,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2021,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.40775,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"niosh_nanotechnology_guidance","type":"regulatory","title":"NIOSH Nanotechnology Guidance and Publications (occupational nanomaterial guidance hub; NIOSH Nanotechnology Research Center field studies cover quantum dots among engineered nanomaterials — no quantum-dot-specific standalone NIOSH document exists)","year":2013,"url":"https://www.cdc.gov/niosh/nano/guidance/index.html"},{"id":"who_nanomaterials_health","type":"regulatory","title":"WHO Guidelines on Protecting Workers from Potential Risks of Manufactured Nanomaterials (2017)","year":2017,"url":"https://www.ncbi.nlm.nih.gov/books/NBK525059/"},{"id":"r60-2026-09-25-d897-niosh-npg-npgd0087","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Cadmium dust (as Cd) (7440-43-9)","url":"https://www.cdc.gov/niosh/npg/npgd0087.html"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:IARC:2021","unmapped_classification:NIOSH:occupational exposure limit","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":21,"warnings":["year_inferred:IARC:2021","unmapped_classification:NIOSH:occupational exposure limit"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","human_child","human_teen","human_elderly","human_infant","human_pregnant"]}