{"hq_id":"hq-c-mix-000027","name":"Quantum dots (CdSe)","context":"human_adult","timestamp":"2026-08-28T01:34:11.879Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.673684,"weightedMean":0.673684,"std_dev":0.299064,"confidence_interval_95":[0.95,0.95],"source_positions":[{"source":"IARC","year":2021,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2021,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2021,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2021,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2021,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.40775,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"niosh_nanotechnology_guidance","type":"regulatory","title":"NIOSH Nanotechnology Guidance and Publications (occupational nanomaterial guidance hub; NIOSH Nanotechnology Research Center field studies cover quantum dots among engineered nanomaterials — no quantum-dot-specific standalone NIOSH document exists)","year":2013,"url":"https://www.cdc.gov/niosh/nano/guidance/index.html"},{"id":"who_nanomaterials_health","type":"regulatory","title":"WHO Guidelines on Protecting Workers from Potential Risks of Manufactured Nanomaterials (2017)","year":2017,"url":"https://www.ncbi.nlm.nih.gov/books/NBK525059/"}],"sources_scope":"context","warnings":["year_inferred:IARC:2021","unmapped_classification:NIOSH:occupational exposure limit","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":15,"warnings":["year_inferred:IARC:2021","unmapped_classification:NIOSH:occupational exposure limit"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","human_child","human_teen","human_elderly","human_infant","human_pregnant"]}