{"hq_id":"hq-c-mix-000025","name":"Nano cerium oxide","context":"human_adult","timestamp":"2026-10-27T21:22:21.369Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-mix-000025","sha256":"f645d8a01570246fd75e651029d44a69b6e2296f02e96edd3b4ca6f794362eab"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"niosh_nanotechnology_guidance","type":"regulatory","title":"NIOSH: Occupational Exposure to Cerium Oxide Nanoparticles — Proposed REL (0.9 μg/m³ as Ce), Biopersistence, Pulmonary Inflammation Evidence, and Diesel Fuel Additive Context","year":2013},{"id":"epa_nano_cerium_oxide","type":"regulatory","title":"US EPA: Nanomaterial Case Studies — Nano Cerium Oxide in Fuel Additives and CMP Applications; Tailpipe Emissions; Biopersistent Pulmonary Hazard; Environmental and Human Health Assessment","year":2014},{"id":"r60-2026-09-28-d899-s1-b03-iris-landing-1018-cerium-oxide","type":"regulatory","title":"Cerium Oxide and Cerium Compounds | CASRN 1306-38-3 | DTXSID4040214 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1018"},{"id":"r60-2026-09-28-d899-s1-b03-pmc-PMC5016214-niosh-fst-metal-oxide-nanoparticles-cmp","type":"regulatory","title":"NIOSH Field Studies Team Assessment: Worker Exposure to Aerosolized Metal Oxide Nanoparticles in a Semiconductor Fabrication Facility - PMC","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5016214/"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-pac-chemical-database-u-s-department-of--cid-73963","type":"database","title":"PAC Chemical Database, U.S. Department of Energy, as recorded by PubChem (Experimental Properties, CID 73963; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/73963/JSON?heading=Experimental+Properties"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: studies indicate no sign","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":49,"warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: studies indicate no sign","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","human_child","human_teen","human_elderly","human_infant","human_pregnant"]}