{"hq_id":"hq-c-mix-000018","name":"PFAS (total) — EPA 2024 drinking water HAL group","context":"human_adult","timestamp":"2026-10-27T21:00:07.675Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-mix-000018","sha256":"44178851848328ee985bd220d87c38411dcac79d4f3ff7de33d98be4e30a22ec"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_pfas_mcl_2024","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulations for PFAS — Final Rule (April 2024): Individual MCLs for PFOA/PFOS (4 ppt), PFNA/PFHxS/HFPO-DA (10 ppt), and Hazard Index for PFAS Mixtures","year":2024},{"id":"iarc_135_pfas","type":"regulatory","title":"IARC Monographs Volume 135 (2023): Perfluorooctanoic Acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) — PFOA classified Group 1 (carcinogenic to humans); PFOS Group 2B (possibly carcinogenic). Other per- and polyfluoroalkyl substances (PFNA, PFHxS, PFUnDA, PFDA, etc.) were NOT individually evaluated in Volume 135.","year":2023},{"id":"r60-2026-09-28-d899-s2-b03-epa-pfas-npdwr","type":"regulatory","title":"Per- and Polyfluoroalkyl Substances (PFAS) | US EPA","url":"https://www.epa.gov/sdwa/and-polyfluoroalkyl-substances-pfas"},{"id":"r60-2026-09-28-d899-s2-b03-epa-pfas-npdwr-fact-sheet-general-2024","type":"regulatory","title":"PFAS National Primary Drinking Water Regulation","url":"https://www.epa.gov/system/files/documents/2024-04/pfas-npdwr_fact-sheet_general_4.9.24v1.pdf"},{"id":"r60-2026-09-28-d899-s2-b03-epa-pfas-npdwr-qa-general-2024","type":"regulatory","title":"Questions & Answers: PFAS National Primary Drinking Water Regulation","url":"https://www.epa.gov/system/files/documents/2024-04/pfas-npdwr_qa_general_4.9.24v1.pdf"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Listing of POPs in the Stockholm Convention","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:US EPA:group 1 carcinogen","unmapped_classification:US EPA:maximum contaminant level (mcl): 4 ng/l (4 ppt)","unmapped_classification:US EPA:maximum contaminant level (mcl): 10 ng/l","unmapped_classification:US EPA:hazard index (hi) ≤ 1","unmapped_classification:Stockholm Convention:annex a/b listed pops — pfos (2009), pfoa (2019), ","unmapped_classification:ECHA:reach universal-pfas restriction proposal (annex x","unmapped_classification:Health Canada:cepa schedule 1 class designation — pfas as a clas","unmapped_classification:AICIS:australia national pfas position statement","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":16,"warnings":["unmapped_classification:US EPA:group 1 carcinogen","unmapped_classification:US EPA:maximum contaminant level (mcl): 4 ng/l (4 ppt)","unmapped_classification:US EPA:maximum contaminant level (mcl): 10 ng/l","unmapped_classification:US EPA:hazard index (hi) ≤ 1","unmapped_classification:Stockholm Convention:annex a/b listed pops — pfos (2009), pfoa (2019), ","unmapped_classification:ECHA:reach universal-pfas restriction proposal (annex x","unmapped_classification:Health Canada:cepa schedule 1 class designation — pfas as a clas","unmapped_classification:AICIS:australia national pfas position statement"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","exposure_ingestion","human_teen","human_elderly","human_infant"]}