{"hq_id":"hq-c-mix-000012","name":"Polybrominated diphenyl ethers (PBDEs)","context":"human_adult","timestamp":"2026-10-27T21:22:21.246Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-mix-000012","sha256":"b4ef84dbaa2be2fefb676a8b201f0e0fe119d6c54e2ac531b2c9e3f816f45ca8"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_pbde_phaseout","type":"regulatory","title":"US EPA: Polybrominated Diphenyl Ethers (PBDEs) — Phase-Out, Risk Assessment, and Ongoing Exposure Assessment","year":2014,"url":"https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/polybrominated-diphenyl-ethers-pbdes"},{"id":"who_endocrine_2012","type":"regulatory","title":"WHO/UNEP: State of the Science of Endocrine Disrupting Chemicals — Brominated Flame Retardants and Persistent Organic Pollutants","year":2012},{"id":"src_iarc_loc_d754","type":"iarc","title":"IARC Monographs — List of Classifications: Decabromodiphenyl oxide, Group 3 (IARC Monographs Volume(s) 48, 71 (1999))","url":"https://monographs.iarc.who.int/list-of-classifications/"},{"id":"r60-2026-10-01-dd54-pops-new-pops","type":"regulatory","title":"Stockholm Convention: The New POPs (the Convention's own index of listed chemicals)","url":"https://www.pops.int/TheConvention/ThePOPs/TheNewPOPs/tabid/2511/Default.aspx"},{"id":"r60-2026-10-02-d983-stockholm-convention-text-2025","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants: text with Annexes (2025 English)","url":"https://www.pops.int/Portals/0/download.aspx?e=UNEP-POPS-COP-CONVTEXT-2025.English.pdf"},{"id":"doc-2026-10-02-2026-10-02-dd43f-atsdr-tp207-pbdes","type":"assessment","title":"ATSDR Toxicological Profile for Polybrominated Diphenyl Ethers (PBDEs), March 2017","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp207.pdf"}],"sources_scope":"context","derived_markers":[],"warnings":["unreadable_classification:absent:IARC","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":21,"warnings":["unreadable_classification:absent:IARC"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","aquatic_life","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}