{"hq_id":"hq-c-mix-000012","name":"Polybrominated diphenyl ethers (PBDEs)","context":"human_adult","timestamp":"2026-08-28T02:24:05.683Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.296053,"weightedMean":0.296053,"std_dev":0.049844,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35},{"source":"IARC","year":1999,"value":0.25,"weight":0.41}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1999,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1999,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1999,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.667707,"disagreement_magnitude":0.310258,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (35th percentile), while IARC concludes lower risk (25th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_pbde_group3","type":"regulatory","title":"IARC: polybrominated diphenyl ethers — classified Group 3 (not classifiable as to carcinogenicity to humans)","year":2023},{"id":"epa_pbde_phaseout","type":"regulatory","title":"US EPA: Polybrominated Diphenyl Ethers (PBDEs) — Phase-Out, Risk Assessment, and Ongoing Exposure Assessment","year":2014},{"id":"who_endocrine_2012","type":"regulatory","title":"WHO/UNEP: State of the Science of Endocrine Disrupting Chemicals — Brominated Flame Retardants and Persistent Organic Pollutants","year":2012}],"sources_scope":"context","warnings":["limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":14},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","aquatic_life","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}