{"hq_id":"hq-c-mix-000008","name":"Nickel compounds","context":"human_adult","timestamp":"2026-10-27T21:14:44.824Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-mix-000008","sha256":"ac3ab3862415979202d4d2256852922dce6bc8b67817bceedcf2b90654ca9ea1"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.782692,"weightedMean":0.782692,"std_dev":0.13275,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"US EPA","year":1986,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41},{"source":"US EPA","year":1986,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41},{"source":"US EPA","year":1986,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41},{"source":"US EPA","year":1986,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41},{"source":"US EPA","year":1986,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.115,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_100c_ni","type":"regulatory","title":"IARC Monographs Volume 100C: Nickel and Nickel Compounds — Arsenic, Metals, Fibres, and Dusts","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304378/"},{"id":"epa_ni_iris","type":"regulatory","title":"US EPA IRIS: Nickel subsulfide — Carcinogenicity Assessment (Group A, human carcinogen by inhalation; IUR 4.8e-4 per µg/m³)","year":1987,"url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=273"},{"id":"atsdr_ni","type":"report","title":"ATSDR Toxicological Profile for Nickel","year":2024,"url":"https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=245&tid=44"},{"id":"r60-2026-09-26-d867-niosh-npg-npgd0445","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Nickel metal and other compounds (as Ni)","url":"https://www.cdc.gov/niosh/npg/npgd0445.html"},{"id":"r60-2026-09-25-d867-ecfr-29cfr1926-subpartD","type":"regulatory","title":"Subpart D—Occupational Health and Environmental Controls","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-29.xml?part=1926&subpart=D"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02008R1272-20260701","type":"regulatory","title":"Consolidated TEXT: 32008R1272 — EN — 01.07.2026 (Regulation (EC) No 1272/2008, CLP; the consolidation applicable on 2026-09-26)","url":"https://publications.europa.eu/resource/celex/02008R1272-20260701"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"}],"sources_scope":"context","derived_markers":[],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":16},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","exposure_dermal","human_teen","human_elderly","human_infant","human_pregnant","exposure_ingestion","exposure_ocular","occupational_exposure"]}