{"hq_id":"hq-c-mix-000007","name":"Hexavalent chromium [Cr(VI)]","context":"human_adult","timestamp":"2026-09-10T14:19:37.072Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.779212,"weightedMean":0.779212,"std_dev":0.125889,"confidence_interval_95":[0.625,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"US EPA","year":2024,"value":0.75,"weight":0.5494},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.734465,"weightedMean":0.734465,"std_dev":0.141616,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41},{"source":"US EPA","year":2024,"value":0.82,"weight":0.5494}]},"recency":{"mean":0.704978,"weightedMean":0.704978,"std_dev":0.192183,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41},{"source":"US EPA","year":2024,"value":0.67,"weight":0.5494}]},"methodology":{"mean":0.919811,"weightedMean":0.919811,"std_dev":0.132765,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41},{"source":"US EPA","year":2024,"value":1,"weight":0.5494}]},"specificity":{"mean":0.795441,"weightedMean":0.795441,"std_dev":0.075233,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41},{"source":"US EPA","year":2024,"value":0.75,"weight":0.5494}]},"consensus":{"exists":false,"strength":0.16074,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_100c_crvi","type":"regulatory","title":"IARC Monographs Volume 100C: Chromium (VI) Compounds — Arsenic, Metals, Fibres, and Dusts","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304377/"},{"id":"epa_crvi_iris","type":"regulatory","title":"US EPA IRIS: Chromium VI — Inhalation Unit Risk (1998 Final; Toxicological Review updated 2024)","year":1998,"url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=144"}],"sources_scope":"context","meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":12},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","exposure_ingestion","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_ocular","occupational_exposure"]}