{"hq_id":"hq-c-mix-000001","name":"PFAS (Per- and Polyfluoroalkyl Substances)","context":"human_adult","timestamp":"2026-10-27T17:12:41.827Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-mix-000001","sha256":"1ffa43800f35463aacadfb665fb80427c000f466cf2414d4e9896f68989bfb32"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.701356,"weightedMean":0.701356,"std_dev":0.060945,"confidence_interval_95":[0.625,0.75],"source_positions":[{"source":"US EPA","year":2024,"value":0.75,"weight":0.5494},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.695473,"weightedMean":0.695473,"std_dev":0.156018,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"US EPA","year":2024,"value":0.82,"weight":0.5494}]},"recency":{"mean":0.798419,"weightedMean":0.798419,"std_dev":0.160894,"confidence_interval_95":[0.67,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"US EPA","year":2024,"value":0.67,"weight":0.5494}]},"methodology":{"mean":0.883256,"weightedMean":0.883256,"std_dev":0.146267,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"US EPA","year":2024,"value":1,"weight":0.5494}]},"specificity":{"mean":0.816155,"weightedMean":0.816155,"std_dev":0.082885,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"US EPA","year":2024,"value":0.75,"weight":0.5494}]},"consensus":{"exists":false,"strength":0.5937,"disagreement_magnitude":0.262992,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":"PFOA classified IARC Group 1 (2023). EPA 2024 MCL 4 ppt. Known immunotoxicant at low exposure levels.","warning":"limited_synthesis"},"sources":[{"id":"src_001","type":"other"},{"id":"src_002","type":"epa","url":"https://www.federalregister.gov/documents/2024/04/26/2024-07773/pfas-national-primary-drinking-water-regulation"},{"id":"src_003","type":"cdc","url":"https://www.atsdr.cdc.gov/pfas/data-research/facts-stats/index.html"},{"id":"src_004","type":"other"},{"id":"src_005","type":"other"},{"id":"src_006","type":"other"},{"id":"src_007","type":"other","url":"https://www.avma.org/news/researcher-looking-pfas-exposure-dogs-cats"},{"id":"src_008","type":"other","url":"https://investors.3m.com/news-events/press-releases/detail/1836/3m-settlement-with-public-water-suppliers-to-address-pfas"},{"id":"src_009","type":"epa","url":"https://www.epa.gov/pfas/key-epa-actions-address-pfas"},{"id":"src_010","type":"other"},{"id":"src_011","type":"other"},{"id":"src_012","type":"other"},{"id":"src_pfoa_dupont_1961","type":"toxicology_record","title":"DuPont 1961 PFOA hepatomegaly findings (Welsh et al., summarized in C-8 trial discovery)","year":1961},{"id":"src_3m_pfas_settlement_2023","type":"court_record","title":"3M $10.3B PFAS public-water-suppliers settlement","year":2023,"url":"https://www.3m.com/3M/en_US/pfas-stewardship-us/"},{"id":"r60-2026-09-26-d867-cc2-epa-drinking-water-health-advisories","type":"regulatory","title":"Drinking Water Health Advisories (HAs) | US EPA","url":"https://www.epa.gov/sdwa/drinking-water-health-advisories-has"},{"id":"r60-2026-09-26-d867-cc2-fr-2022-13158-pfas-health-advisories","type":"regulatory","title":"Federal Register, Volume 87 Issue 118 (Tuesday, June 21, 2022)","url":"https://www.govinfo.gov/content/pkg/FR-2022-06-21/html/2022-13158.htm"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Listing of POPs in the Stockholm Convention","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-28-d899-s2-b03-epa-pfas-npdwr","type":"regulatory","title":"Per- and Polyfluoroalkyl Substances (PFAS) | US EPA (Final PFAS NPDWR; last updated May 18, 2026)","url":"https://www.epa.gov/sdwa/and-polyfluoroalkyl-substances-pfas"},{"id":"r60-iarc-135-pfoa-group1","type":"regulatory","title":"IARC Monographs Volume 135: Perfluorooctanoic Acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) (2023)","url":"https://www.ncbi.nlm.nih.gov/books/NBK614282/"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"doc-2026-10-02-d975-www-atsdr-cdc-gov-toxprofiles-tp200-pdf","type":"assessment","title":"Toxicological Profile for Perfluoroalkyls (ATSDR, Released May 2021)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp200.pdf"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IARC:not classified as a class","unmapped_classification:Stockholm Convention:annex b (restriction) — pfos, its salts, and pfosf","unmapped_classification:Stockholm Convention:annex a (elimination) — pfoa, its salts, and pfoa-","unmapped_classification:Stockholm Convention:annex a (elimination) — pfhxs, its salts, and pfhx","unmapped_classification:ECHA:reach annex xvii restriction — pfoa and related su","unmapped_classification:ECHA:reach svhc candidate list — multiple pfas (pfoa, p","unmapped_classification:Health Canada:cepa schedule 1 toxic substance — pfos, pfoa, lc-p","unmapped_classification:AICIS:industrial chemicals (notification and assessment)","unmapped_classification:METI:cscl class i specified chemical substance — pfos","unmapped_classification:K-REACH:restricted substance — pfos, pfoa, pfhxs","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":22,"warnings":["unmapped_classification:IARC:not classified as a class","unmapped_classification:Stockholm Convention:annex b (restriction) — pfos, its salts, and pfosf","unmapped_classification:Stockholm Convention:annex a (elimination) — pfoa, its salts, and pfoa-","unmapped_classification:Stockholm Convention:annex a (elimination) — pfhxs, its salts, and pfhx","unmapped_classification:ECHA:reach annex xvii restriction — pfoa and related su","unmapped_classification:ECHA:reach svhc candidate list — multiple pfas (pfoa, p","unmapped_classification:Health Canada:cepa schedule 1 toxic substance — pfos, pfoa, lc-p","unmapped_classification:AICIS:industrial chemicals (notification and assessment)","unmapped_classification:METI:cscl class i specified chemical substance — pfos","unmapped_classification:K-REACH:restricted substance — pfos, pfoa, pfhxs"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","human_pregnant","dog","cat","aquatic_life","human_teen","human_elderly","human_infant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}