{"hq_id":"hq-c-ino-000225","name":"Cobalt(II) oxide (CoO)","context":"human_adult","timestamp":"2026-09-10T09:55:31.432Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.543795,"weightedMean":0.543795,"std_dev":0.200354,"confidence_interval_95":[0.3,0.8],"source_positions":[{"source":"CalEPA","year":1992,"value":0.8,"weight":0.41},{"source":"IARC","year":2023,"value":0.5,"weight":0.45018},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.727452,"weightedMean":0.727452,"std_dev":0.145087,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2023,"value":0.82,"weight":0.45018},{"source":"CalEPA","year":1992,"value":0.82,"weight":0.41}]},"recency":{"mean":0.662834,"weightedMean":0.662834,"std_dev":0.216059,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2023,"value":0.549,"weight":0.45018},{"source":"CalEPA","year":1992,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.913236,"weightedMean":0.913236,"std_dev":0.136019,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2023,"value":1,"weight":0.45018},{"source":"CalEPA","year":1992,"value":1,"weight":0.41}]},"specificity":{"mean":0.799166,"weightedMean":0.799166,"std_dev":0.077078,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2023,"value":0.75,"weight":0.45018},{"source":"CalEPA","year":1992,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.304861,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_002","type":"reference","title":"ATSDR Toxicological Profile for Cobalt (October 2024) — Chemical and Physical Information","year":2024,"url":"https://www.ncbi.nlm.nih.gov/books/NBK609988/"}],"sources_scope":"context","meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":2},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["aquatic_life","exposure_ingestion","human_adult","human_child","human_teen","human_elderly","human_infant","human_pregnant"]}