{"hq_id":"hq-c-ino-000225","name":"Cobalt(II) oxide (CoO)","context":"human_adult","timestamp":"2026-10-27T18:07:22.067Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000225","sha256":"9d448f00b7797f0c6464c3c0e76c418f4167625351eee3849a9348982e75eeca"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.543795,"weightedMean":0.543795,"std_dev":0.200354,"confidence_interval_95":[0.3,0.8],"source_positions":[{"source":"CalEPA","year":1992,"value":0.8,"weight":0.41},{"source":"IARC","year":2023,"value":0.5,"weight":0.45018},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.727452,"weightedMean":0.727452,"std_dev":0.145087,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2023,"value":0.82,"weight":0.45018},{"source":"CalEPA","year":1992,"value":0.82,"weight":0.41}]},"recency":{"mean":0.662834,"weightedMean":0.662834,"std_dev":0.216059,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2023,"value":0.549,"weight":0.45018},{"source":"CalEPA","year":1992,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.913236,"weightedMean":0.913236,"std_dev":0.136019,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2023,"value":1,"weight":0.45018},{"source":"CalEPA","year":1992,"value":1,"weight":0.41}]},"specificity":{"mean":0.799166,"weightedMean":0.799166,"std_dev":0.077078,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2023,"value":0.75,"weight":0.45018},{"source":"CalEPA","year":1992,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.304861,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_002","type":"reference","title":"ATSDR Toxicological Profile for Cobalt (October 2024) — Chemical and Physical Information","year":2024,"url":"https://www.ncbi.nlm.nih.gov/books/NBK609988/"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02008R1272-20260701","type":"regulatory","title":"Consolidated TEXT: 32008R1272 — EN — 01.07.2026 (Regulation (EC) No 1272/2008, CLP; the consolidation applicable on 2026-09-26)","url":"https://publications.europa.eu/resource/celex/02008R1272-20260701"}],"sources_scope":"context","derived_markers":[],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":6},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["aquatic_life","exposure_ingestion","human_adult","human_child","human_teen","human_elderly","human_infant","human_pregnant"]}