{"hq_id":"hq-c-ino-000159","name":"Beryllium sulfate","context":"human_adult","timestamp":"2026-10-27T20:23:19.405Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000159","sha256":"c87a074f6e86a581e17cdca7869dbb484333e26d070425337805355e38c2c2fe"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.673684,"weightedMean":0.673684,"std_dev":0.299064,"confidence_interval_95":[0.35,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.40775,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"src_001","type":"reference","title":"ATSDR Toxicological Profile — CAS 13510-49-1","url":"https://www.atsdr.cdc.gov/toxprofiledocs/index.html"},{"id":"iarc_100c_beryllium_beryllium_compounds","type":"regulatory","title":"IARC Monographs Volume 100C: Arsenic, Metals, Fibres, and Dusts","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304379/"},{"id":"osha_beryllium_standard_29cfr1910_1024","type":"regulatory","title":"OSHA 29 CFR 1910.1024 — Beryllium Standard (PEL 0.2 µg Be/m³ TWA + STEL 2.0 µg/m³ 15-min + Action Level 0.1 µg/m³; medical-surveillance + dermal-protection + housekeeping framework; finalized 2017 + 2020 amendments)","year":2020,"url":"https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1024"},{"id":"niosh_beryllium_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Beryllium and compounds (REL Lowest Feasible Concentration; 'Ca' carcinogen + Sen sensitizer designation; aerospace + nuclear + dental-laboratory + recycling cohort framework)","year":2019,"url":"https://www.cdc.gov/niosh/npg/npgd0054.html"},{"id":"atsdr_beryllium_tox_profile","type":"regulatory","title":"ATSDR Toxicological Profile for Beryllium and Beryllium Compounds (CERCLA Substance Priority List top-50; Chronic Beryllium Disease (CBD) hypersensitivity-mediated granulomatous-lung cohort framework + Be-LTT lymphocyte-transformation-test diagnostic framework)","year":2002,"url":"https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=1441&tid=33"},{"id":"epa_beryllium_iris_naaqs","type":"regulatory","title":"US EPA IRIS — Beryllium and compounds (inhalation unit risk 2.4E-3 (µg/m³)⁻¹; chronic RfD 0.002 mg/kg-day; Class B1 Probable Human Carcinogen; National Emission Standard for Hazardous Air Pollutants — Beryllium 40 CFR 61 Subpart C framework)","year":1998,"url":"https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=12"},{"id":"kreiss_beryllium_sensitization_2007","type":"study","title":"Kreiss K, Day GA, Schuler CR — Beryllium: a modern industrial hazard (canonical Cu-Be + machining + recycling + dental-laboratory CBD + sensitization-cohort framework + sub-PEL exposures)","year":2007,"url":"https://pubmed.ncbi.nlm.nih.gov/17094767/"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"pubchem-computed-cid-26077","type":"database","title":"PubChem computed properties for CID 26077 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/26077"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-26077","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 26077; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/26077/JSON?heading=Experimental+Properties"},{"id":"pubchem-computed-structure-cid-26077","type":"database","title":"PubChem computed structure descriptors for CID 26077 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/26077"}],"sources_scope":"record","derived_markers":[],"warnings":["unreadable_classification:absent:EPA","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":13,"warnings":["unreadable_classification:absent:EPA"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_teen","human_elderly","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}