{"hq_id":"hq-c-ino-000154","name":"Lead(II) chloride","context":"human_adult","timestamp":"2026-10-27T20:02:16.723Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000154","sha256":"92716d2413ba114f6dd04b3e9cd548437b678a37a8f56210e28e4f2b2290993e"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.538816,"weightedMean":0.538816,"std_dev":0.174454,"confidence_interval_95":[0.35,0.7],"source_positions":[{"source":"IARC","year":2006,"value":0.7,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2006,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2006,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2006,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2006,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.344616,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"src_001","type":"reference","title":"ATSDR Toxicological Profile — CAS 7758-95-4","url":"https://www.atsdr.cdc.gov/toxprofiledocs/index.html"},{"id":"src_iarc_loc_d754","type":"iarc","title":"IARC Monographs — List of Classifications: Lead compounds, inorganic, Group 2A (IARC Monographs Volume(s) Sup 7, 87 (2006))","url":"https://monographs.iarc.who.int/list-of-classifications/"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1025","type":"regulatory","title":"§ 1910.1025 Lead.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1025"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-24459","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 24459; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/24459/JSON?heading=Experimental+Properties"},{"id":"pubchem-computed-structure-cid-24459","type":"database","title":"PubChem computed structure descriptors for CID 24459 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/24459"}],"sources_scope":"record","derived_markers":[],"warnings":["unreadable_classification:absent:EPA","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":13,"warnings":["unreadable_classification:absent:EPA"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_teen","human_elderly","human_pregnant"]}