{"hq_id":"hq-c-ino-000131","name":"Nitrous oxide","context":"human_adult","timestamp":"2026-10-27T21:24:00.219Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000131","sha256":"1f6450c37efabb1f2be0340369b04ee6fada2c478a038bdc300e818384aa08fb"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"src_001","type":"database","title":"PubChem","year":2026},{"id":"niosh_n2o_wag_rel","type":"regulatory","title":"NIOSH Recommended Exposure Limit — Waste Anesthetic Gases (N2O 25 ppm TWA)","year":1977},{"id":"osha_n2o_medical_dental","type":"regulatory","title":"OSHA Anesthetic Gases — Guidelines for Workplace Exposures (medical/dental N2O)","year":2000},{"id":"rowland_n2o_pregnancy_1992","type":"primary_literature","title":"Rowland et al. — Reduced fertility and pregnancy loss among female dental assistants exposed to N2O","year":1992},{"id":"fda_n2o_recreational_warning_2024","type":"regulatory","title":"FDA warning — recreational N2O ('whippets') subacute combined-degeneration B12 myeloneuropathy","year":2024},{"id":"r60-2026-10-01-npg-npgd0465-nitrous-oxide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards: Nitrous oxide","url":"https://www.cdc.gov/niosh/npg/npgd0465.html"},{"id":"pubchem-computed-cid-948","type":"database","title":"PubChem computed properties for CID 948 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/948"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"src_pubchem_exp_948","type":"pubchem","title":"PubChem: Experimental Properties section (CID 948)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/948/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-cameo-chemicals-cid-948","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 948; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/948/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid8021066","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID8021066 (Nitrous oxide)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID8021066"},{"id":"pubchem-computed-structure-cid-948","type":"database","title":"PubChem computed structure descriptors for CID 948 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/948"}],"sources_scope":"record","derived_markers":[],"warnings":["single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":11},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","human_teen","human_elderly","human_pregnant","exposure_dermal","exposure_ingestion","exposure_ocular","occupational_exposure"]}