{"hq_id":"hq-c-ino-000102","name":"Bromate (BrO3−), from ozone-bromine reactions","context":"human_adult","timestamp":"2026-10-27T20:03:45.310Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-ino-000102","sha256":"3beace95673902aa4258602ae9c7d453d7bf2cac91bc30ad2633f50d7d0e75ab"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.600646,"weightedMean":0.600646,"std_dev":0.229814,"confidence_interval_95":[0.3,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.70254,"weightedMean":0.70254,"std_dev":0.154241,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.599983,"weightedMean":0.599983,"std_dev":0.304626,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.889882,"weightedMean":0.889882,"std_dev":0.144601,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.8124,"weightedMean":0.8124,"std_dev":0.081941,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.405764,"warning":null},"outliers":[{"source":"HQ_DIRECT","value":0.3}]},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"src_001","type":"database","title":"PubChem Compound CID 84979","url":"https://pubchem.ncbi.nlm.nih.gov/compound/84979"},{"id":"src_002","type":"epa","title":"EPA CompTox Chemicals Dashboard — DTXSID8023923","url":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023923"},{"id":"src_003","type":"reference","title":"ATSDR Toxicological Profile — CAS 15541-45-4","url":"https://www.atsdr.cdc.gov/toxprofiledocs/index.html"},{"id":"r60-2026-09-27-d899-who-gdwq-4th-ed-addenda-2026-pdftotext","type":"regulatory","title":"Guidelines for drinking-water quality: fourth edition incorporating the first, second and third addenda","url":"https://iris.who.int/server/api/core/bitstreams/c60cc28e-defe-45ed-b157-71fdd43902bf/content"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-28-d899-s2-b02-iris-landing-1002-bromate","type":"regulatory","title":"Bromate | CASRN 15541-45-4 | DTXSID8023923 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1002"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":40,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / IRIS:carcinogenic potential cannot be determined"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["exposure_inhalation","human_adult","human_child","human_teen","human_elderly","human_infant","human_pregnant"]}